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APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 452197, updated on 3-Apr-2024

Summary

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Official Symbol
APPL2provided by VGNC
Official Full Name
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2provided by VGNC
Primary source
VGNC:VGNC:8593
Locus tag
CK820_G0016036
See related
Ensembl:ENSPTRG00000005384
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (111991211..112054614, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (110613936..110677554, complement)

Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene NOP protein chaperone 1 Neighboring gene aldehyde dehydrogenase 1 family member L2 Neighboring gene WASH complex subunit 4 Neighboring gene chromosome 12 C12orf75 homolog Neighboring gene uncharacterized LOC134807506

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DCC-interacting protein 13-beta
Names
DIP13 beta
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
amyloid beta (A4) precursor-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    111991211..112054614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001160746.6 → XP_001160746.1  DCC-interacting protein 13-beta isoform X2

    See identical proteins and their annotated locations for XP_001160746.1

    UniProtKB/TrEMBL
    A0A2I3RVJ6, A0A2J8MZR2, A0A803KJL2, K7BNS7
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:482 → 615
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  2. XM_054664640.2 → XP_054520615.1  DCC-interacting protein 13-beta isoform X7

  3. XM_016924096.3 → XP_016779585.1  DCC-interacting protein 13-beta isoform X5

    UniProtKB/TrEMBL
    A0A2J8MZR5

  4. XM_509331.7 → XP_509331.2  DCC-interacting protein 13-beta isoform X1

    UniProtKB/TrEMBL
    A0A2I3RVJ6, A0A2J8MZR7, A0A6D2Y0H2, H2Q6S0
    Related
    ENSPTRP00000009143.3
    Conserved Domains (3) summary
    cd07632
    Location:20 → 240
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:488 → 621
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:258 → 382
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  5. XM_063787080.1 → XP_063643150.1  DCC-interacting protein 13-beta isoform X8

  6. XM_063787079.1 → XP_063643149.1  DCC-interacting protein 13-beta isoform X6

    UniProtKB/TrEMBL
    A0A2I3SWR1, A0A2J8MZR1, A0A6D2VZB4

  7. XM_009426143.5 → XP_009424418.1  DCC-interacting protein 13-beta isoform X4

    UniProtKB/TrEMBL
    A0A2I3RVJ6
    Conserved Domains (4) summary
    cd13158
    Location:445 → 578
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:215 → 339
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
    pfam00169
    Location:241 → 338
    PH; PH domain
    cl12013
    Location:1 → 197
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  8. XM_001160596.6 → XP_001160596.1  DCC-interacting protein 13-beta isoform X6

    UniProtKB/TrEMBL
    A0A2I3RVJ6, A0A2I3SWR1, A0A2J8MZR1, A0A6D2VZB4
    Related
    ENSPTRP00000081023.1
    Conserved Domains (3) summary
    cd13158
    Location:439 → 572
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:209 → 333
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 191
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_054664641.2 → XP_054520616.1  DCC-interacting protein 13-beta isoform X8

  10. XM_016924095.3 → XP_016779584.1  DCC-interacting protein 13-beta isoform X4

    UniProtKB/TrEMBL
    A0A2I3RVJ6
    Conserved Domains (4) summary
    cd13158
    Location:445 → 578
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:215 → 339
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
    pfam00169
    Location:241 → 338
    PH; PH domain
    cl12013
    Location:1 → 197
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_063787077.1 → XP_063643147.1  DCC-interacting protein 13-beta isoform X3

Nucleotide Protein
Heading Accession and Version

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