LTA4H leukotriene A4 hydrolase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: LTA4Hprovided by VGNC
Official Full Name: leukotriene A4 hydrolaseprovided by VGNC
Primary source: VGNC:VGNC:5460
Locus tag: CK820_G0016198
See related: Ensembl:ENSPTRG00000005321
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (102841550..102876533, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (101462036..101496915, complement)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D12S2087 (e-PCR)
- UniSTS:473634

D12S206 (e-PCR)
- UniSTS:81699

D12S1883 (e-PCR)
- UniSTS:21576

D12S206 (e-PCR)
- UniSTS:148899

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables epoxide hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables leukotriene-A4 hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leukotriene A-4 hydrolase

NP_001267011.1

EC 3.3.2.6

XP_063640861.1

EC 3.3.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001280082.1 → NP_001267011.1 leukotriene A-4 hydrolase

See identical proteins and their annotated locations for NP_001267011.1

Status: PROVISIONAL

Source sequence(s)

AK306704

UniProtKB/TrEMBL

A0A2I3T185, G2HIZ0

Related

ENSPTRP00000009041.2, ENSPTRT00000009777.3

Conserved Domains (3) summary

cd09599
Location:6 → 450

M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase

TIGR02411
Location:6 → 608

leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase

pfam09127
Location:468 → 607

Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

102841550..102876533 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)