LRP1 LDL receptor related protein 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: LRP1provided by VGNC
Official Full Name: LDL receptor related protein 1provided by VGNC
Primary source: VGNC:VGNC:5459
Locus tag: CK820_G0035479
See related: Ensembl:ENSPTRG00000005122
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 89

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (38819789..38905100, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (37489642..37574931, complement)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

SHGC-141809 (e-PCR)
- UniSTS:171090

D12S113E (e-PCR)
- UniSTS:147353

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables low-density lipoprotein particle receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prolow-density lipoprotein receptor-related protein 1

Names: low density lipoprotein receptor-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

38819789..38905100 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016924881.4 → XP_016780370.1 prolow-density lipoprotein receptor-related protein 1 isoform X1

UniProtKB/TrEMBL

A0A2I3S3K1, A0A2J8KWD1, A0A2J8KWD7, A0A6D2X5U5

Related

ENSPTRP00000071154.1

Conserved Domains (10) summary

smart00192
Location:3493 → 3526

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:3094 → 3136

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2982 → 3011

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:3575 → 3609

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:4013 → 4053

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl00104
Location:71 → 104

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam12662
Location:2962 → 2985

cEGF; Complement Clr-like EGF-like

pfam14670
Location:807 → 842

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:140 → 187

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

cl26742
Location:2253 → 2463

SGL; SMP-30/Gluconolaconase/LRE-like region
XM_016924882.4 → XP_016780371.1 prolow-density lipoprotein receptor-related protein 1 isoform X2

UniProtKB/TrEMBL

A0A2J8KWD7