CBL Cbl proto-oncogene [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: CBLprovided by VGNC
Official Full Name: Cbl proto-oncogeneprovided by VGNC
Primary source: VGNC:VGNC:10188
Locus tag: CK820_G0015674
See related: Ensembl:ENSPTRG00000004378
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	9	NC_072407.2 (121150160..121255339)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	11	NC_072409.1 (120369018..120478156)

Chromosome 9 - NC_072407.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

CBL (e-PCR)
- UniSTS:46104

RH103536 (e-PCR)
- UniSTS:97861

PMC86017P1 (e-PCR)
- UniSTS:273505

RH93709 (e-PCR)
- UniSTS:89958

GDB:198117 (e-PCR)
- UniSTS:156019

STS-X57110 (e-PCR)
- UniSTS:51828

WI-14589 (e-PCR)
- UniSTS:1963

D11S1941E (e-PCR)
- UniSTS:53441

CBL_4518 (e-PCR)
- UniSTS:462794

WI-8978 (e-PCR)
- UniSTS:8926

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of epidermal growth factor-activated receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase CBL

Names: Cas-Br-M (murine) ecotropic retroviral transforming sequence; Cbl proto-oncogene, E3 ubiquitin protein ligase

XP_001165648.1

EC 2.3.2.27

XP_016777635.1

EC 2.3.2.27

XP_063639544.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

121150160..121255339

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001165648.6 → XP_001165648.1 E3 ubiquitin-protein ligase CBL isoform X1

See identical proteins and their annotated locations for XP_001165648.1

UniProtKB/TrEMBL

A0A2I3RXE8, A0A2J8N272, A0A2J8N281, A0A6D2WBH2, A0A6D2XCW5, H2Q4Y2

Related

ENSPTRP00000007497.3

Conserved Domains (6) summary

cd09920
Location:256 → 352

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14393
Location:857 → 896

UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins

pfam02262
Location:54 → 175

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:179 → 262

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:362 → 427

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cl26464
Location:480 → 810

Atrophin-1; Atrophin-1 family
XM_016922146.4 → XP_016777635.1 E3 ubiquitin-protein ligase CBL isoform X2

UniProtKB/TrEMBL

A0A2I3RXE8, A0A2J8N281, A0A6D2WBH2
XM_063783474.1 → XP_063639544.1 E3 ubiquitin-protein ligase CBL isoform X2