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DRD2 dopamine receptor D2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 451553, updated on 29-Mar-2024

Summary

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Official Symbol
DRD2provided by VGNC
Official Full Name
dopamine receptor D2provided by VGNC
Primary source
VGNC:VGNC:3283
Locus tag
CK820_G0034347
See related
Ensembl:ENSPTRG00000004295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 9 NC_072407.2 (115383089..115448751, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 11 NC_072409.1 (114605959..114671628, complement)

Chromosome 9 - NC_072407.2Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene uncharacterized LOC134807380 Neighboring gene transmembrane serine protease 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of a D2 dopamine receptor intron within the great apes and humans. Deinard AS, et al. DNA Seq, 1998. PMID 10993600
  2. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipase C-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
D(2) dopamine receptor
Names
D2 dopamine receptor
dopamine D2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033928.1 → NP_001029100.1  D(2) dopamine receptor

    See identical proteins and their annotated locations for NP_001029100.1

    Status: PROVISIONAL

    Source sequence(s)
    AY665279
    UniProtKB/TrEMBL
    A0A2J8L035
    Related
    ENSPTRP00000069210.1, ENSPTRT00000104721.1
    Conserved Domains (2) summary
    pfam00001
    Location:51 → 426
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:49 → 233
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    115383089..115448751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016919832.3 → XP_016775321.1  D(2) dopamine receptor isoform X2

    UniProtKB/TrEMBL
    A0A2I3TGE7, A0A2J8L035, A0A2J8L038, A0A6D2W4T6
    Related
    ENSPTRP00000088340.1
    Conserved Domains (1) summary
    cd15309
    Location:35 → 408
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_016919830.3 → XP_016775319.1  D(2) dopamine receptor isoform X1

    UniProtKB/Swiss-Prot
    P60026, Q5IS49
    UniProtKB/TrEMBL
    A0A2J8L026, A0A2J8L035
    Conserved Domains (1) summary
    cd15309
    Location:35 → 437
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_016919831.4 → XP_016775320.1  D(2) dopamine receptor isoform X1

    UniProtKB/Swiss-Prot
    P60026, Q5IS49
    UniProtKB/TrEMBL
    A0A2J8L026, A0A2J8L035
    Conserved Domains (1) summary
    cd15309
    Location:35 → 437
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60026.1 GenPept UniProtKB/Swiss-Prot:P60026

Gene LinkOut

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