ALOX5 arachidonate 5-lipoxygenase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: ALOX5provided by VGNC
Official Full Name: arachidonate 5-lipoxygenaseprovided by VGNC
Primary source: VGNC:VGNC:51965
Locus tag: CK820_G0054503
See related: Ensembl:ENSPTRG00000002458
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	8	NC_072406.2 (58243036..58313203)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	10	NC_072408.1 (48913006..48983157)

Chromosome 8 - NC_072406.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RH79041 (e-PCR)
- UniSTS:44581

RH102744 (e-PCR)
- UniSTS:97078

RH17822 (e-PCR)
- UniSTS:71005

SHGC-59903 (e-PCR)
- UniSTS:34693

RH98891 (e-PCR)
- UniSTS:91527

WI-9162 (e-PCR)
- UniSTS:78319

RH40180 (e-PCR)
- UniSTS:87536

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables arachidonate 5-lipoxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hepoxilin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in linoleic acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid oxidation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipoxygenase pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: arachidonate 5-lipoxygenase; polyunsaturated fatty acid 5-lipoxygenase

XP_016773660.1

EC 1.13.11.34

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

58243036..58313203

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016918171.3 → XP_016773660.1 polyunsaturated fatty acid 5-lipoxygenase

UniProtKB/TrEMBL

A0A2J8IP81, A0A2J8IP95, A0A6D2WSU7, H2Q1U9

Related

ENSPTRP00000066851.1

Conserved Domains (2) summary

cd01753
Location:2 → 115

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

cl27717
Location:227 → 665

Lipoxygenase; Lipoxygenase