U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD4 CD4 molecule [ Pan troglodytes (chimpanzee) ]

Gene ID: 450124, updated on 29-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CD4provided by VGNC
Official Full Name
CD4 moleculeprovided by VGNC
Primary source
VGNC:VGNC:5330
Locus tag
CK820_G0048139
See related
Ensembl:ENSPTRG00000004590
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CD4 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (13971855..14003044)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (12621584..12652819)

Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin Neighboring gene lymphocyte activating 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene prolyl 3-hydroxylase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV). Warren CJ, et al. Proc Natl Acad Sci U S A, 2019 Jun 4. PMID 31113887, Free PMC Article
  2. Genetic subspecies diversity of the chimpanzee CD4 virus-receptor gene. Hvilsom C, et al. Genomics, 2008 Nov. PMID 18718520
  3. A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site. Camerini D, et al. Cell, 1990 Mar 9. PMID 2107024
  4. Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus. Fomsgaard A, et al. Eur J Immunol, 1992 Nov. PMID 1425921

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in interleukin-15-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
T-cell surface glycoprotein CD4
Names
CD4 antigen (p55)
T-cell surface antigen T4/Leu-3
lymphocyte antigen CD4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009043.1 → NP_001009043.1  T-cell surface glycoprotein CD4 precursor

    See identical proteins and their annotated locations for NP_001009043.1

    Status: PROVISIONAL

    Source sequence(s)
    M31135
    UniProtKB/Swiss-Prot
    P16004
    UniProtKB/TrEMBL
    A0A0E3T6P3, A0A2J8JEL8, A0A410S7F1, A0A4P9Q224, A0A663D762, B0LAF4, B0LAH5, B0LAI4, K7AM69
    Related
    ENSPTRP00000054833.3, ENSPTRT00000062277.3
    Conserved Domains (5) summary
    cd07690
    Location:28 → 121
    Ig1_CD4; First immunoglobulin (Ig) domain of CD4
    cd07694
    Location:123 → 204
    Ig2_CD4; Second immunoglobulin (Ig) domain of CD4
    pfam12104
    Location:426 → 453
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam05790
    Location:317 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:208 → 316
    CD4-extracel; CD4, extracellular

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    13971855..14003044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016922513.4 → XP_016778002.1  T-cell surface glycoprotein CD4 isoform X2

  2. XM_016922510.4 → XP_016777999.1  T-cell surface glycoprotein CD4 isoform X1

    UniProtKB/Swiss-Prot
    P16004
    UniProtKB/TrEMBL
    A0A0E3T6P3, A0A2J8JEL8, A0A410S7F1, A0A4P9Q224, A0A663D762, B0LAF4, B0LAH5, B0LAI4, K7AM69
    Conserved Domains (5) summary
    cd07690
    Location:28 → 121
    Ig1_CD4; First immunoglobulin (Ig) domain of CD4
    cd07694
    Location:123 → 204
    Ig2_CD4; Second immunoglobulin (Ig) domain of CD4
    pfam12104
    Location:426 → 453
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam05790
    Location:317 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:208 → 316
    CD4-extracel; CD4, extracellular
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16004.1 GenPept UniProtKB/Swiss-Prot:P16004

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous