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PAK3 p21 (RAC1) activated kinase 3 [ Pan troglodytes (chimpanzee) ]

Gene ID: 450118, updated on 3-Apr-2024

Summary

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Official Symbol
PAK3provided by VGNC
Official Full Name
p21 (RAC1) activated kinase 3provided by VGNC
Primary source
VGNC:VGNC:10463
Locus tag
CK820_G0034850
See related
Ensembl:ENSPTRG00000022187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) X NC_072421.2 (108446610..108731535)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) X NC_072421.1 (108442691..108727617)

Chromosome X - NC_072421.2Genomic Context describing neighboring genes Neighboring gene cation-dependent mannose-6-phosphate receptor-like Neighboring gene chordin like 1 Neighboring gene calpain 6 Neighboring gene doublecortin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases. Rousseau V, et al. J Biol Chem, 2003 Feb 7. PMID 12464619
  2. Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. Kitano T, et al. Mol Biol Evol, 2003 Aug. PMID 12777533

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 3
Names
PAK-3
beta-PAK
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21-activated kinase 3
NP_001009039.1
XP_009437779.1
XP_009437780.1
XP_009437781.1
XP_009437782.1
XP_009437783.1
XP_009437785.1
XP_009437786.1
XP_009437787.1
XP_009437788.1
XP_009437789.1
XP_009437790.1
XP_009437791.1
XP_009437792.1
XP_009437793.1
XP_009437794.1
XP_016798115.1
XP_016798116.1
XP_016798117.1
XP_016798118.1
XP_016798119.1
XP_054532159.1
XP_054532160.1
XP_054532161.1
XP_063659847.1
XP_063659848.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009039.1 → NP_001009039.1  serine/threonine-protein kinase PAK 3

    See identical proteins and their annotated locations for NP_001009039.1

    Status: PROVISIONAL

    Source sequence(s)
    AB102660
    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Related
    ENSPTRP00000092335.1, ENSPTRT00000079025.1
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072421.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    108446610..108731535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016942629.4 → XP_016798118.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  2. XM_063803778.1 → XP_063659848.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2J8KYD9

  3. XM_054676184.2 → XP_054532159.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2J8KYD9

  4. XM_009439514.5 → XP_009437789.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437789.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  5. XM_009439513.5 → XP_009437788.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437788.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  6. XM_009439511.5 → XP_009437786.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437786.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  7. XM_009439508.5 → XP_009437783.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437783.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  8. XM_054676185.2 → XP_054532160.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A6D2WKX1, K7CPU0

  9. XM_009439519.5 → XP_009437794.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_009437794.1

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  10. XM_009439518.5 → XP_009437793.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_009437793.1

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  11. XM_009439517.5 → XP_009437792.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_009437792.1

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  12. XM_054676186.2 → XP_054532161.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A6D2WKX1, K7CPU0

  13. XM_009439512.5 → XP_009437787.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437787.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  14. XM_009439515.5 → XP_009437790.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437790.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  15. XM_009439506.5 → XP_009437781.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437781.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  16. XM_009439510.5 → XP_009437785.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437785.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  17. XM_063803777.1 → XP_063659847.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2J8KYD9

  18. XM_009439505.5 → XP_009437780.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437780.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Related
    ENSPTRP00000041645.3
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  19. XM_009439504.5 → XP_009437779.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437779.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  20. XM_009439507.5 → XP_009437782.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_009437782.1

    UniProtKB/Swiss-Prot
    Q7YQL4
    UniProtKB/TrEMBL
    A0A2I3TMY4, A0A2J8KYD7, A0A2J8KYD9, A0A6D2WJ53
    Conserved Domains (2) summary
    cd06656
    Location:263 → 559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 141
    PBD; P21-Rho-binding domain

  21. XM_016942626.4 → XP_016798115.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Related
    ENSPTRP00000070572.1
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  22. XM_009439516.5 → XP_009437791.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_009437791.1

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  23. XM_016942627.4 → XP_016798116.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  24. XM_016942628.4 → XP_016798117.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  25. XM_016942630.4 → XP_016798119.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KYD0, A0A2J8KYE1, A0A6D2WKX1, K7CPU0
    Conserved Domains (2) summary
    cd06656
    Location:248 → 544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YQL4.1 GenPept UniProtKB/Swiss-Prot:Q7YQL4

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