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amt aminomethyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 450000, updated on 27-Mar-2024

Summary

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Official Symbol
amtprovided by ZNC
Official Full Name
aminomethyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-114
See related
Ensembl:ENSDARG00000010862 AllianceGenome:ZFIN:ZDB-GENE-041010-114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc31f04; wu:fc31f04; wu:fd44b12; wu:fd54h12; zgc:103483; zgc:109741
Summary
Predicted to enable aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to act upstream of or within glycine catabolic process and methylation. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; eye; optic tectum; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (26396575..26408839)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (26377436..26389700)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-20d21.12 Neighboring gene hyaluronidase 3 Neighboring gene N-acetyltransferase 6 Neighboring gene interferon-related developmental regulator 2 Neighboring gene zgc:136971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. He Z, et al. Biochem Biophys Res Commun, 2019 Sep 10. PMID 31349972, Free PMC Article
  2. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
  3. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aminomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aminomethyltransferase, mitochondrial
NP_001006021.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006021.1 → NP_001006021.1  aminomethyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001006021.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083400
    UniProtKB/TrEMBL
    Q5XJA4
    Related
    ENSDARP00000081585.3, ENSDART00000087151.5
    Conserved Domains (3) summary
    PLN02319
    Location:2 → 407
    PLN02319; aminomethyltransferase
    pfam01571
    Location:46 → 298
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:307 → 399
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    26396575..26408839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394726.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1547..8384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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