APOE apolipoprotein E [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: APOEprovided by VGNC
Official Full Name: apolipoprotein Eprovided by VGNC
Primary source: VGNC:VGNC:57935
Locus tag: CK820_G0049411
See related: Ensembl:ENSPTRG00000011127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	20	NC_072418.2 (47862141..47865637)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	19	NC_072417.1 (47862165..47865661)

Chromosome 20 - NC_072418.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
Title: The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes).
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
Title: Apolipoprotein E phylogeny and evolution.

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General gene information

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Markers

PMC99927P2 (e-PCR)
- UniSTS:273705

GDB:438097 (e-PCR)
- UniSTS:157265

STS-N29699 (e-PCR)
- UniSTS:34644

STS-K00396 (e-PCR)
- UniSTS:64138

GDB:169570 (e-PCR)
- UniSTS:154765

GDB:171177 (e-PCR)
- UniSTS:154776

PMC310963P3 (e-PCR)
- UniSTS:272826

PMC310963P4 (e-PCR)
- UniSTS:272827

GDB:181693 (e-PCR)
- UniSTS:155329

RH11470 (e-PCR)
- UniSTS:72925

PMC117303P1 (e-PCR)
- UniSTS:270328

GDB:177380 (e-PCR)
- UniSTS:154875

GDB:196979 (e-PCR)
- UniSTS:155901

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables very-low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipoprotein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
part_of intermediate-density lipoprotein particle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: apolipoprotein E

Names: apo-E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.