IL4 interleukin 4 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: IL4provided by VGNC
Official Full Name: interleukin 4provided by VGNC
Primary source: VGNC:VGNC:4046
Locus tag: CK820_G0026770
See related: Ensembl:ENSPTRG00000044483
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	4	NC_072402.2 (130432078..130440601)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	5	NC_072403.1 (130450712..130459235)

Chromosome 4 - NC_072402.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

REN71232 (e-PCR)
- UniSTS:396032

ECD00749 (e-PCR)
- UniSTS:281858

REN71236 (e-PCR)
- UniSTS:396036

REN71237 (e-PCR)
- UniSTS:396037

REN71238 (e-PCR)
- UniSTS:396038

REN71239 (e-PCR)
- UniSTS:396039

REN71240 (e-PCR)
- UniSTS:396040

REN71241 (e-PCR)
- UniSTS:396041

REN71242 (e-PCR)
- UniSTS:396042

REN71243 (e-PCR)
- UniSTS:396043

REN71244 (e-PCR)
- UniSTS:396044

REN71245 (e-PCR)
- UniSTS:396045

REN71246 (e-PCR)
- UniSTS:396046

REN71247 (e-PCR)
- UniSTS:396047

REN71248 (e-PCR)
- UniSTS:396048

REN71249 (e-PCR)
- UniSTS:396049

REN71250 (e-PCR)
- UniSTS:396050

REN71251 (e-PCR)
- UniSTS:396051

REN71252 (e-PCR)
- UniSTS:396052

REN71253 (e-PCR)
- UniSTS:396053

REN71254 (e-PCR)
- UniSTS:396054

REN71255 (e-PCR)
- UniSTS:396055

REN71256 (e-PCR)
- UniSTS:396056

REN71257 (e-PCR)
- UniSTS:396057

REN71258 (e-PCR)
- UniSTS:396058

REN71259 (e-PCR)
- UniSTS:396059

REN71260 (e-PCR)
- UniSTS:396060

REN71261 (e-PCR)
- UniSTS:396061

REN71262 (e-PCR)
- UniSTS:396062

REN71263 (e-PCR)
- UniSTS:396063

ECD12380 (e-PCR)
- UniSTS:293413

GDB:456299 (e-PCR)
- UniSTS:157483

stSG601440 (e-PCR)
- UniSTS:444245

stSG601441 (e-PCR)
- UniSTS:444246

stSG601442 (e-PCR)
- UniSTS:444247

stSG601444 (e-PCR)
- UniSTS:444249

stSG601445 (e-PCR)
- UniSTS:444250

stSG601446 (e-PCR)
- UniSTS:444251

stSG601447 (e-PCR)
- UniSTS:444252

ECD07045 (e-PCR)
- UniSTS:288103

ECD20165 (e-PCR)
- UniSTS:301169

ECD08604 (e-PCR)
- UniSTS:289652

IL4 (e-PCR), detects polymorphism
- UniSTS:479899

GDB:180248 (e-PCR)
- UniSTS:155064

GDB:207332 (e-PCR)
- UniSTS:156119

ECD19759 (e-PCR)
- UniSTS:300763

PMC324417P1 (e-PCR)
- UniSTS:273131

ECD01760 (e-PCR)
- UniSTS:282861

REN71218 (e-PCR)
- UniSTS:396018

REN71220 (e-PCR)
- UniSTS:396020

REN71221 (e-PCR)
- UniSTS:396021

REN71222 (e-PCR)
- UniSTS:396022

REN71223 (e-PCR)
- UniSTS:396023

ECD08735 (e-PCR)
- UniSTS:289783

REN71224 (e-PCR)
- UniSTS:396024

REN71225 (e-PCR)
- UniSTS:396025

REN71226 (e-PCR)
- UniSTS:396026

REN71227 (e-PCR)
- UniSTS:396027

REN71228 (e-PCR)
- UniSTS:396028

REN71229 (e-PCR)
- UniSTS:396029

REN71230 (e-PCR)
- UniSTS:396030

REN71231 (e-PCR)
- UniSTS:396031

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-4 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell costimulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in activation of Janus kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info	PubMed
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of T-helper 17 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of macrophage activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MHC class II biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of eosinophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of isotype switching to IgE isotypes	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mononuclear cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: interleukin-4

Names: B-cell stimulatory factor 1; BSF-1; IL-4; lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008993.1 → NP_001008993.1 interleukin-4 isoform delta2 precursor

See identical proteins and their annotated locations for NP_001008993.1

Status: PROVISIONAL

Source sequence(s)

AY130261

UniProtKB/TrEMBL

A0A140TAX8, A0A2J8LS46, A0A6D2Y6I5

Related

ENSPTRP00000065391.1, ENSPTRT00000088624.1

Conserved Domains (1) summary

pfam00727
Location:28 → 133

IL4; Interleukin 4
NM_001011714.1 → NP_001011714.1 interleukin-4 isoform 1 precursor

See identical proteins and their annotated locations for NP_001011714.1

Status: PROVISIONAL

Source sequence(s)

AY130260

UniProtKB/TrEMBL

A0A140TAX8, A0A2J8LS46, A0A6D2Y6I5

Related

ENSPTRP00000071542.1, ENSPTRT00000101449.1

Conserved Domains (1) summary

pfam00727
Location:28 → 149

IL4; Interleukin 4

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

130432078..130440601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024356477.2 → XP_024212245.1 interleukin-4 isoform X1

UniProtKB/TrEMBL

A0A2I3SZ99, A0A2J8LS27, A0A6D2WSL3

Conserved Domains (1) summary

cl11518
Location:1 → 77

IL4; Interleukin 4