LIFR LIF receptor subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: LIFRprovided by VGNC
Official Full Name: LIF receptor subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:42672
See related: Ensembl:ENSCAFG00845003525
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (70845522..70892699)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (70004435..70051591)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (71245697..71292862)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (70593619..70640769)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (70707131..70754284)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data show that LIFR is highly co-expressed with adrenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH) in the canine pituitary gland and in corticotrope adenomas
Title: Expression of leukemia inhibitory factor and leukemia inhibitory factor receptor in the canine pituitary gland and corticotrope adenomas.
There was no allelic association between a polymorphic microsatellite marker and pituitary dwarfism in German Shepherd dogs in this study.
Title: The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs.
each subunit of the CNTF receptor complex has a distinct distribution in polarised cells which may reflect the different roles the respective cytokines play in vivo
Title: Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables leukemia inhibitory factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oncostatin-M receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leukemia inhibitory factor receptor

Names: LIF receptor alpha; LIF-R; leukemia inhibitory factor receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005760.1 → NP_001005760.1 leukemia inhibitory factor receptor precursor

See identical proteins and their annotated locations for NP_001005760.1

Status: PROVISIONAL

Source sequence(s)

AY745241

UniProtKB/Swiss-Prot

Q5XNR9

UniProtKB/TrEMBL

A0A8C0KI50, A0A8I3MM33

Related

ENSCAFP00845004988.1, ENSCAFT00845006282.1

Conserved Domains (2) summary

cd00063
Location:433 → 530

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:552 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...