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AKT2 AKT serine/threonine kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 449021, updated on 5-Mar-2024

Summary

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Official Symbol
AKT2provided by VGNC
Official Full Name
AKT serine/threonine kinase 2provided by VGNC
Primary source
VGNC:VGNC:37772
See related
Ensembl:ENSCAFG00845003888
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (113957825..114008296)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (112790741..112808659)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (114172976..114190895)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (113546597..113564514)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (113179139..113197049)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene phospholipase D family member 3 Neighboring gene chromosome 1 C19orf47 homolog Neighboring gene cyclin P Neighboring gene mitogen-activated protein kinase kinase kinase 10 Neighboring gene tetratricopeptide repeat domain 9B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunohistochemical evaluation of AKT protein activation in canine mast cell tumours. Rodriguez S, et al. J Comp Pathol, 2012 Aug-Oct. PMID 22289273, Free PMC Article
  2. The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis. Bachelder RE, et al. J Biol Chem, 2001 Sep 14. PMID 11463786
  3. Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt. Huang Y, et al. Am J Physiol Lung Cell Mol Physiol, 2020 May 1. PMID 32130030, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.
    Title: Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.
  2. Canine mast cell tumours cells have activated AKT protein.
    Title: Immunohistochemical evaluation of AKT protein activation in canine mast cell tumours.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAC-beta serine/threonine-protein kinase
Names
protein kinase B
NP_001012340.1
XP_038509395.1
XP_038509396.1
XP_038509397.1
XP_038509398.1
XP_038509399.1
XP_038509400.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012340.1 → NP_001012340.1  RAC-beta serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001012340.1

    Status: PROVISIONAL

    Source sequence(s)
    AY833721
    UniProtKB/TrEMBL
    A0A8C0KNN1, Q5I9W5
    Related
    ENSCAFP00845005612.1, ENSCAFT00845007039.1
    Conserved Domains (3) summary
    cd05595
    Location:94 → 416
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    smart00220
    Location:90 → 347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    113957825..114008296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653468.1 → XP_038509396.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LUB4, A0A8I3MS98, A0A8P0PR31
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:156 → 391
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038653467.1 → XP_038509395.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LUB4, A0A8I3MS98, A0A8P0PR31
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:156 → 391
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038653471.1 → XP_038509399.1  RAC-beta serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I3MS98, A0A8P0PR31
    Related
    ENSCAFP00845005632.1, ENSCAFT00845007062.1
    Conserved Domains (2) summary
    cl17171
    Location:4 → 68
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:113 → 348
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038653472.1 → XP_038509400.1  RAC-beta serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8C0KNN1, A0A8C0SCK1, A0A8I3MNQ3
    Related
    ENSCAFP00845005645.1, ENSCAFT00845007077.1
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  5. XM_038653469.1 → XP_038509397.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LUB4, A0A8I3MS98, A0A8P0PR31
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:156 → 391
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038653470.1 → XP_038509398.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LUB4, A0A8I3MS98, A0A8P0PR31
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:156 → 391
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    113546597..113564514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    113179139..113197049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    114172976..114190895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    112790741..112808659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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