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eEF1gamma eukaryotic translation elongation factor 1 gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44791, updated on 4-Apr-2024

Summary

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Official Symbol
eEF1gammaprovided by FlyBase
Official Full Name
eukaryotic translation elongation factor 1 gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0029176
Locus tag
Dmel_CG11901
See related
AllianceGenome:FB:FBgn0029176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11901; Dmel\CG11901; EF1 gamma; Ef1Bggr; Ef1gamma; EF1gamma; Ef1y
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Located in cytoplasm and nucleus. Is expressed in adult head; adult heart; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
99A1-99A1; 3-98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29220172..29222109)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25045894..25047831)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA::CR31044 Neighboring gene mir-279 stem loop Neighboring gene mir-996 stem loop Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene Bromodomain containing 8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein kinase Darkener of apricot and its substrate EF1γ regulate organelle transport along microtubules. Serpinskaya AS, et al. J Cell Sci, 2014 Jan 1. PMID 24163433, Free PMC Article
  2. Rapid adaptive radiation and host plant conservation in the Hawaiian picture wing Drosophila (Diptera: Drosophilidae). Magnacca KN, et al. Mol Phylogenet Evol, 2015 Nov. PMID 26151218
  3. Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions. Tavares L, et al. Glia, 2015 Jul. PMID 25731761
  4. Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability. Fan Y, et al. Genetics, 2010 Jan. PMID 19841092, Free PMC Article
  5. Multiple In Vivo Biological Processes Are Mediated by Functionally Redundant Activities of Drosophila mir-279 and mir-996. Sun K, et al. PLoS Genet, 2015 Jun. PMID 26042831, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOA protein and its substrate EF-1gamma regulate organelle transport along microtubules.
    Title: Protein kinase Darkener of apricot and its substrate EF1γ regulate organelle transport along microtubules.
  2. EF1gamma functions in vital cellular processes in addition to translational elongation and is a LAMMER kinase substrate in vivo.
    Title: Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation elongation factor 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation elongation factor 1 gamma
Names
CG11901-PA
CG11901-PB
CG11901-PC
Ef1gamma
eEF1gamma-PA
eEF1gamma-PB
eEF1gamma-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29220172..29222109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202379.2 → NP_001189308.1  eukaryotic translation elongation factor 1 gamma, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189308.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3K9, Q6NL63, Q8IGT6, Q9NJH0, Q9NJH1, Q9VAM7
    UniProtKB/TrEMBL
    A0A0B4JD11
    Conserved Domains (4) summary
    cd03181
    Location:90 → 209
    GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
    COG0625
    Location:5 → 187
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03044
    Location:4 → 79
    GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
    pfam00647
    Location:271 → 376
    EF1G; Elongation factor 1 gamma, conserved domain

  2. NM_170401.3 → NP_733280.1  eukaryotic translation elongation factor 1 gamma, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733280.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3K9, Q6NL63, Q8IGT6, Q9NJH0, Q9NJH1, Q9VAM7
    UniProtKB/TrEMBL
    A0A0B4JD11
    Related
    FBpp0084761
    Conserved Domains (4) summary
    cd03181
    Location:90 → 209
    GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
    COG0625
    Location:5 → 187
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03044
    Location:4 → 79
    GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
    pfam00647
    Location:271 → 376
    EF1G; Elongation factor 1 gamma, conserved domain

  3. NM_143743.3 → NP_652000.1  eukaryotic translation elongation factor 1 gamma, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652000.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3K9, Q6NL63, Q8IGT6, Q9NJH0, Q9NJH1, Q9VAM7
    UniProtKB/TrEMBL
    A0A0B4JD11
    Related
    FBpp0084762
    Conserved Domains (4) summary
    cd03181
    Location:90 → 209
    GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
    COG0625
    Location:5 → 187
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03044
    Location:4 → 79
    GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
    pfam00647
    Location:271 → 376
    EF1G; Elongation factor 1 gamma, conserved domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD11 A0A0B4JD11
Q9NJH0.2 Q9NJH0

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