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sc5d sterol-C5-desaturase [ Danio rerio (zebrafish) ]

Gene ID: 447891, updated on 27-Mar-2024

Summary

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Official Symbol
sc5dprovided by ZNC
Official Full Name
sterol-C5-desaturaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-56
See related
Ensembl:ENSDARG00000044642 AllianceGenome:ZFIN:ZDB-GENE-040912-56
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sc5dl; zgc:101732
Summary
Predicted to enable C-5 sterol desaturase activity. Acts upstream of or within response to yeast. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SC5D (sterol-C5-desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (24531679..24535441, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (24495074..24498836, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC798286 Neighboring gene cell adhesion molecule 1a Neighboring gene Rho GTPase activating protein 32b Neighboring gene anaphase promoting complex subunit 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regeneration Rosetta: An Interactive Web Application To Explore Regeneration-Associated Gene Expression and Chromatin Accessibility. Rau A, et al. G3 (Bethesda), 2019 Dec 3. PMID 31575636, Free PMC Article
  2. Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Xu Y, et al. Front Endocrinol (Lausanne), 2022. PMID 35547009, Free PMC Article
  3. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
  4. zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Castillo-Castellanos F, et al. Life Sci, 2021 Nov 1. PMID 34453946
  5. Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Pinto CL, et al. Mol Cell Endocrinol, 2016 Jan 5. PMID 26427652, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables C-5 sterol desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta7-sterol 5(6)-desaturase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process via lathosterol IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lathosterol oxidase
Names
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like
NP_001004630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004630.1 → NP_001004630.1  lathosterol oxidase

    See identical proteins and their annotated locations for NP_001004630.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081395
    UniProtKB/TrEMBL
    Q66ID6
    Related
    ENSDARP00000065599.4, ENSDART00000065600.5
    Conserved Domains (2) summary
    COG3000
    Location:42 → 257
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:123 → 253
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    24531679..24535441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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