Coprox Coproporphyrinogen oxidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Coproxprovided by FlyBase
Official Full Name: Coproporphyrinogen oxidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0021944
Locus tag: Dmel_CG3433
See related: AllianceGenome:FB:FBgn0021944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM14838; CG3433; Dmel\CG3433; l(2)k10617; l(2)k11018
Summary: Predicted to enable coproporphyrinogen oxidase activity and protein homodimerization activity. Predicted to be involved in protoporphyrinogen IX biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6964421..6965887)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6964421..6965887)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables coproporphyrinogen oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables coproporphyrinogen oxidase activity	IEA Inferred from Electronic Annotation more info
enables coproporphyrinogen oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Names: CG3433-PA; CG3433-PB; Coprox-PA; Coprox-PB; corpoporphyrinogen III oxidase

NP_001285697.1

NP_524777.1

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The following sections contain reference sequences that belong to a specific genome build. Explain