SmD1 Small ribonucleoprotein particle protein SmD1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SmD1provided by FlyBase
Official Full Name: Small ribonucleoprotein particle protein SmD1provided by FlyBase
Primary source: FLYBASE:FBgn0261933
Locus tag: Dmel_CG10753
See related: AllianceGenome:FB:FBgn0261933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE39488; CG10753; D1-Sm; dD1; Dmel\CG10753; l(2)SH3 003; l(3)SH003; smd1; snRNP; snRNP-69D; snRNP69D
Summary: Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including central nervous system and extended germ band embryo. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12733364..12734611, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12726464..12727711, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in spliceosomal snRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal snRNP assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SMN-Sm protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U12-type spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U4 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	HDA more info	PubMed
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of commitment complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of pICln-Sm protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of precatalytic spliceosome	HDA more info	PubMed
part_of precatalytic spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of small nuclear ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of spliceosomal tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG10753-PA; SmD1-PA; lethal (3) SH003; small nuclear ribonucleoprotein at 69D

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The following sections contain reference sequences that belong to a specific genome build. Explain