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COMT catechol-O-methyltransferase [ Canis lupus familiaris (dog) ]

Gene ID: 445450, updated on 5-Mar-2024

Summary

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Official Symbol
COMTprovided by VGNC
Official Full Name
catechol-O-methyltransferaseprovided by VGNC
Primary source
VGNC:VGNC:39501
See related
Ensembl:ENSCAFG00845028665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (30763075..30783341, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (29318554..29324118, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (29522581..29528148, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (28811616..28817179, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (28436974..28442538, complement)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA mir-185 Neighboring gene ARVCF delta catenin family member Neighboring gene thioredoxin reductase 2 Neighboring gene G protein subunit beta 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours. Canadas A, et al. Vet Comp Oncol, 2018 Dec. PMID 30168237
  2. Association between COMT SNP variation and timidity in Golden and Labrador Retrievers. Luo D, et al. Anim Genet, 2018 Aug. PMID 29932467
  3. Influence of catechol-O-methyltransferase (COMT) genotypes on the prognosis of canine mammary tumors. Dias Pereira P, et al. Vet Pathol, 2009 Nov. PMID 19605895
  4. Breed differences in genotype and allele frequency of catechol O-methyltransferase gene polymorphic regions in dogs. Masuda K, et al. J Vet Med Sci, 2004 Feb. PMID 15031547
  5. Catechol-O-methyltransferase and the clinical features of psychosis. McClay JL, et al. Am J Med Genet B Neuropsychiatr Genet, 2006 Dec 5. PMID 16921496

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNPs associated with progression and biological behavior of mammary tumors
    Title: Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours.
  2. genotypes and haplotypes of the COMT gene were significantly and highly correlated with the timidity of Golden and Labrador Retrievers
    Title: Association between COMT SNP variation and timidity in Golden and Labrador Retrievers.
  3. Dogs carrying both known polymorphisms of COMT were more likely to develop recurrence of mammary lesions.
    Title: Influence of catechol-O-methyltransferase (COMT) genotypes on the prognosis of canine mammary tumors.
  4. A functional polymorphism (Val-158-Met) at the Catechol-O-methyltransferase (COMT) locus confers a modest affective vulnerability to psychosis.
    Title: Catechol-O-methyltransferase and the clinical features of psychosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables catechol O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in catecholamine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
catechol O-methyltransferase
Names
O-methyltransferase
NP_001004074.1
XP_038292001.1
XP_038292002.1
XP_038292003.1
XP_038292004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004074.1 → NP_001004074.1  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_001004074.1

    Status: PROVISIONAL

    Source sequence(s)
    AY340812
    UniProtKB/TrEMBL
    A0A8P0SIL1, Q60F99, Q69FG4, Q69FG6
    Related
    ENSCAFP00845039737.1, ENSCAFT00845050690.1
    Conserved Domains (1) summary
    pfam13578
    Location:63 → 171
    Methyltransf_24; Methyltransferase domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    30763075..30783341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436073.1 → XP_038292001.1  catechol O-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8C0NTN1, A0A8I3Q5W5
    Related
    ENSCAFP00845039727.1, ENSCAFT00845050677.1
    Conserved Domains (1) summary
    COG4122
    Location:49 → 241
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

  2. XM_038436074.1 → XP_038292002.1  catechol O-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8C0NTN1, A0A8I3Q5W5
    Conserved Domains (1) summary
    COG4122
    Location:49 → 241
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

  3. XM_038436075.1 → XP_038292003.1  catechol O-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8C0NTN1, A0A8I3Q5W5
    Conserved Domains (1) summary
    COG4122
    Location:49 → 241
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

  4. XM_038436076.1 → XP_038292004.1  catechol O-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8C0NTN1, A0A8I3Q5W5
    Conserved Domains (1) summary
    COG4122
    Location:49 → 241
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    28811616..28817179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    28436974..28442538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    29522581..29528148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29318554..29324118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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