sars1 seryl-tRNA synthetase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sars1provided by ZNC
Official Full Name: seryl-tRNA synthetase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040831-1
See related: Ensembl:ENSDARG00000008237 AllianceGenome:ZFIN:ZDB-GENE-040831-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sars; SerRS; zgc:92152; wu:fk51f08
Summary: Enables serine-tRNA ligase activity. Involved in negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor production; and seryl-tRNA aminoacylation. Acts upstream of or within branching involved in blood vessel morphogenesis; cerebellum vasculature development; and regulation of vasculature development. Located in nucleus. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (34030574..34043651)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (34104043..34117120)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identified a nuclear localization signal sequence embedded in UNE-S domain and showed that the essential role of SerRS in vascular development is dependent on UNE-S and its role to mobilize SerRS from the cytoplasm to the nucleus
Title: Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
SARS regulates endothelial sprouting. These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development.
Title: Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development.

Submit: New GeneRIF Correction

General gene information

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Markers

fk51f08.x1 (e-PCR)
- UniSTS:201111

MARC_7385-7386:996687849:1 (e-PCR)
- UniSTS:269780

fb78h05.x1 (e-PCR)
- UniSTS:191455

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables serine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables serine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular endothelial growth factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in seryl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in seryl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within seryl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in seryl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: serine--tRNA ligase, cytoplasmic

Names: adr; adrasteia; unm s277; unm_s277

NP_001003882.1

EC 6.1.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.