U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rfc5 replication factor C (activator 1) 5 [ Danio rerio (zebrafish) ]

Gene ID: 445385, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
rfc5provided by ZNC
Official Full Name
replication factor C (activator 1) 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-040907-1
See related
Ensembl:ENSDARG00000035634 AllianceGenome:ZFIN:ZDB-GENE-040907-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110313
Summary
Predicted to enable ATP binding activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Acts upstream of or within retina development in camera-type eye. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rfc5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (12528734..12549746)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (12028517..12049529)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 1 (neuronal) Neighboring gene kinase suppressor of ras 2 Neighboring gene zgc:171242 Neighboring gene si:dkey-98f17.5 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene microRNA 22b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Heme regulates exocrine peptidase precursor genes in zebrafish. Wang H, et al. Exp Biol Med (Maywood), 2007 Oct. PMID 17895525
  2. Identification of zebrafish insertional mutants with defects in visual system development and function. Gross JM, et al. Genetics, 2005 May. PMID 15716491, Free PMC Article
  3. Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Kashyap B, et al. Reprod Toxicol, 2014 Jan. PMID 24355176, Free PMC Article
  4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
replication factor C subunit 5
Names
replication factor C subunit RFC5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003862.1 → NP_001003862.1  replication factor C subunit 5

    See identical proteins and their annotated locations for NP_001003862.1

    Status: PROVISIONAL

    Source sequence(s)
    AY648755
    UniProtKB/TrEMBL
    A0A8M1N1T8, Q6DRK4
    Related
    ENSDARP00000051669.4, ENSDART00000051670.5
    Conserved Domains (4) summary
    cd00009
    Location:29 → 170
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PRK00440
    Location:12 → 323
    rfc; replication factor C small subunit; Reviewed
    pfam08542
    Location:252 → 321
    Rep_fac_C; Replication factor C C-terminal domain
    pfam16193
    Location:186 → 214
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    12528734..12549746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous