ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndufv1provided by ZNC
Official Full Name: NADH:ubiquinone oxidoreductase core subunit V1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040808-73
See related: Ensembl:ENSDARG00000036438 AllianceGenome:ZFIN:ZDB-GENE-040808-73
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86620; wu:fc01f01; wu:fc12f12
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (9212057..9228512)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (9293132..9309587)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI601853 (e-PCR)
- UniSTS:206180

fc01f01.x1 (e-PCR)
- UniSTS:203658

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Names: NADH dehydrogenase (ubiquinone) flavoprotein 1

NP_001003747.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003747.1 → NP_001003747.1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

See identical proteins and their annotated locations for NP_001003747.1

Status: PROVISIONAL

Source sequence(s)

BC078648

UniProtKB/TrEMBL

A0A8M1N1T1, Q6AZA2

Related

ENSDARP00000052929.5, ENSDART00000052930.6

Conserved Domains (4) summary

PRK13596
Location:66 → 487

PRK13596; NADH dehydrogenase I subunit F; Provisional

pfam01512
Location:111 → 280

Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit

pfam10531
Location:306 → 358

SLBB; SLBB domain

pfam10589
Location:397 → 478

NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region