U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

traf3 TNF receptor-associated factor 3 [ Danio rerio (zebrafish) ]

Gene ID: 445119, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
traf3provided by ZNC
Official Full Name
TNF receptor-associated factor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-257
See related
Ensembl:ENSDARG00000022000 AllianceGenome:ZFIN:ZDB-GENE-040801-257
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92367
Summary
Predicted to enable tumor necrosis factor receptor binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within response to yeast. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 17
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (29226464..29249415, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (29210539..29232201, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886905 Neighboring gene uncharacterized LOC101886944 Neighboring gene REST corepressor 1 Neighboring gene ankyrin repeat domain 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional characterization of tumor necrosis factor receptor-associated factor 3 of sea perch (Lateolabrax japonicas) in innate immune. Zhang W, et al. Fish Shellfish Immunol, 2018 Apr. PMID 29407611
  2. Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination. Jin Y, et al. Front Immunol, 2019. PMID 31849979, Free PMC Article
  3. MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination. Liu W, et al. Viruses, 2020 Feb 27. PMID 32120903, Free PMC Article
  4. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. He BL, et al. PLoS One, 2012. PMID 22615868, Free PMC Article
  5. RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I. Lai Y, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30508673

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TNF receptor-associated factor 3
NP_001003513.1
XP_021322821.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003513.1 → NP_001003513.1  TNF receptor-associated factor 3

    See identical proteins and their annotated locations for NP_001003513.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077157
    UniProtKB/TrEMBL
    A0A8M1N1B0, Q6DEG0
    Related
    ENSDARP00000038596.7, ENSDART00000031458.8
    Conserved Domains (4) summary
    smart00184
    Location:55 → 92
    RING; Ring finger
    cd03777
    Location:383 → 568
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:139 → 194
    zf-TRAF; TRAF-type zinc finger
    cl09111
    Location:249 → 322
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    29226464..29249415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467146.1 → XP_021322821.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PKN5
    Conserved Domains (5) summary
    cd03777
    Location:356 → 541
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:139 → 192
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:54 → 95
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl25732
    Location:244 → 363
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26974
    Location:70 → 123
    MAT1; CDK-activating kinase assembly factor MAT1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.