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g6pc1a.1 glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 445118, updated on 27-Mar-2024

Summary

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Official Symbol
g6pc1a.1provided by ZNC
Official Full Name
glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-031001-4
See related
Ensembl:ENSDARG00000031616 AllianceGenome:ZFIN:ZDB-GENE-031001-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
g6pc; cb822; g6pca; g6pca.1; zgc:92368
Summary
Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in gluconeogenesis and glucose 6-phosphate metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in digestive system; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (6021725..6034056, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5989885..6000335, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-131k2.2 Neighboring gene K(lysine) acetyltransferase 7b Neighboring gene uncharacterized LOC110440138 Neighboring gene prostaglandin E synthase 3 like Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 2 Neighboring gene alanyl-tRNA synthetase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. Wang Y, et al. Gen Comp Endocrinol, 2015 Apr 1. PMID 25745818
  2. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Fang L, et al. Br J Nutr, 2014 Mar 14. PMID 24112146
  3. Liver toxicity of macrolide antibiotics in zebrafish. Zhang MQ, et al. Toxicology, 2020 Aug. PMID 32454074
  4. Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish. Brun NR, et al. Commun Biol, 2019. PMID 31646185, Free PMC Article
  5. Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. Li M, et al. J Endocrinol, 2015 Nov. PMID 26446275, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glucose-6-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1
Names
glucose-6-phosphatase a, catalytic, tandem duplicate 1
glucose-6-phosphatase, catalytic
NP_001003512.2
NP_001303265.1
XP_009304709.1
XP_017213936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003512.2 → NP_001003512.2  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX248126, EH484431, EH520605
    UniProtKB/TrEMBL
    A0A8M1N1J9, F1Q559
    Related
    ENSDARP00000116534.1, ENSDART00000139419.3
    Conserved Domains (2) summary
    COG0671
    Location:35 → 197
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03381
    Location:38 → 261
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

  2. NM_001316336.1 → NP_001303265.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    BX248126, EH484431, EH488933, EH494161, EH520605
    UniProtKB/TrEMBL
    A0A8M1P7S6, E7F5Z2
    Related
    ENSDARP00000030904.7, ENSDART00000032050.8
    Conserved Domains (1) summary
    cd03381
    Location:38 → 231
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    6021725..6034056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358447.2 → XP_017213936.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z3H1

  2. XM_009306434.3 → XP_009304709.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform X1

    See identical proteins and their annotated locations for XP_009304709.1

    UniProtKB/TrEMBL
    A0A8M1N1J9, F1Q559
    Conserved Domains (2) summary
    COG0671
    Location:35 → 197
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03381
    Location:38 → 261
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...
Nucleotide Protein Strain
Heading Accession and Version

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