Cbp80 cap binding protein 80 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cbp80provided by FlyBase
Official Full Name: cap binding protein 80provided by FlyBase
Primary source: FLYBASE:FBgn0022942
Locus tag: Dmel_CG7035
See related: AllianceGenome:FB:FBgn0022942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cbp80; CBP80; CG7035; Dmel\CG7035; EG:84H4.3
Summary: Predicted to enable RNA cap binding activity and mRNA binding activity. Involved in negative regulation of viral genome replication; primary miRNA processing; and production of siRNA involved in RNA interference. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; organism; and ovary. Orthologous to human NCBP1 (nuclear cap binding protein subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4650015..4658259)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4544048..4552292)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
part_of nuclear cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cap binding complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
located_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

Names: CG7035-PA; CG7035-PB; Cap binding protein 80; Cap-binding protein 80; Cbp80-PA; Cbp80-PB

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