ADRB3 adrenoceptor beta 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ADRB3provided by VGNC
Official Full Name: adrenoceptor beta 3provided by VGNC
Primary source: VGNC:VGNC:37677
See related: Ensembl:ENSCAFG00845013526
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: B3AR; GPCR
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (29344866..29346061)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (27962835..27964030)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (28183588..28184783)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (27566781..27567975)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (28144259..28145454)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structure of the beta3-adrenergic receptor reveals the molecular basis of subtype selectivity.
Title: Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.
B3AR stimulation resulted in atrial dilation and exacerbated atrial dysfunction in the rapid pacing canine model of Atrial Fibrillation.
Title: The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation.
In conclusion, after HF, beta3-ANT improves LV diastolic filling; increases LV contractility, LV arterial coupling, and mechanical efficiency; and improves exercise performance.
Title: β3-Adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure.
The Adrenergic beta-3 Receptor was upregulated in paced atria, which contributed to oxidative stress and exacerbated atrial structural remodeling by regulating p38 MAPK.
Title: Upregulation of β3-adrenergic receptors contributes to atrial structural remodeling in rapid pacing induced atrial fibrillation canines.

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General gene information

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Markers

ADRB3 (e-PCR)
- UniSTS:262000

ADRB3 (e-PCR)
- UniSTS:506234

MARC_68773-68774:1209743884:2 (e-PCR)
- UniSTS:528345

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta3-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables epinephrine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables norepinephrine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-3 adrenergic receptor

Names: adrenergic, beta-3-, receptor; beta 3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.