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JAK1 Janus kinase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 442952, updated on 11-Apr-2024

Summary

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Official Symbol
JAK1provided by VGNC
Official Full Name
Janus kinase 1provided by VGNC
Primary source
VGNC:VGNC:42175
See related
Ensembl:ENSCAFG00845004547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (45434808..45591981)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (45310150..45467121)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (45594991..45751867)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (45401193..45555602)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (45345182..45501830)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106558823 Neighboring gene 60S ribosomal protein L31-like Neighboring gene microRNA mir-101-1 Neighboring gene proteasome maturation protein-like Neighboring gene uncharacterized LOC111095925 Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene cache domain containing 1 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK1
Names
Janus kinase 1 (a protein tyrosine kinase)
protein tyrosine kinase
NP_001274055.1
XP_038520009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287126.2 → NP_001274055.1  tyrosine-protein kinase JAK1

    See identical proteins and their annotated locations for NP_001274055.1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000371
    UniProtKB/TrEMBL
    A0A8C0MB55
    Related
    ENSCAFP00845006415.1, ENSCAFT00845008163.1
    Conserved Domains (6) summary
    cd05079
    Location:869 → 1152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426 → 526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582 → 845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147 → 277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:36 → 129
    FERM_F1; FERM F1 ubiquitin-like domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    45434808..45591981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664081.1 → XP_038520009.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MB55
    Conserved Domains (6) summary
    cd05079
    Location:869 → 1152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426 → 526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582 → 845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147 → 277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:36 → 129
    FERM_F1; FERM F1 ubiquitin-like domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    45401193..45555602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    45345182..45501830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    45594991..45751867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    45310150..45467121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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