IGF1R insulin like growth factor 1 receptor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IGF1Rprovided by VGNC
Official Full Name: insulin like growth factor 1 receptorprovided by VGNC
Primary source: VGNC:VGNC:41896
See related: Ensembl:ENSCAFG00845001742
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	3	NC_051807.1 (42203106..42506274)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	3	NC_006585.4 (44494039..44797005)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	3	NC_049224.1 (42179556..42481580)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	3	NC_049263.1 (41727974..42030799)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	3	NC_049744.1 (41958900..42261698)

Chromosome 3 - NC_051807.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gene and protein expression of IGF1 and its receptor (IGF1R) in preovulatory follicles and in the CL of pregnant and non-pregnant dogs, were examined.
Title: Expression of insulin-like growth factor 1 and its receptor in preovulatory follicles and in the corpus luteum in the bitch.
It was concluded that IGF-1R is expressed and plays a role in canine osteosarcoma and that its expression is correlated with a poor prognosis.
Title: Increased expression of insulin-like growth factor-1 receptor is correlated with worse survival in canine appendicular osteosarcoma.
The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs.
Title: The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs.
This study provides some evidence that interactions exist between the IGF-IR and these apoptosis-associated proteins may contribute to the development and progression of canine mammary gland tumors.
Title: Relationship between receptors for insulin-like growth factor- I, steroid hormones and apoptosis-associated proteins in canine mammary tumors.

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Pathways from PubChem

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General gene information

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Markers

IGF1R (e-PCR)
- UniSTS:503091

BAC_385-P13 (e-PCR)
- UniSTS:262728

FH2320 (e-PCR)
- UniSTS:263559

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of JNK cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
part_of insulin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 1 receptor

Names: receptor tyrosine kinase

XP_013967871.1

EC 2.7.10.1

XP_038327719.1

EC 2.7.10.1

XP_038327720.1

EC 2.7.10.1

XP_038327721.1

EC 2.7.10.1

XP_038388645.1

EC 2.7.10.1

XP_038388646.1

EC 2.7.10.1

XP_038388647.1

EC 2.7.10.1

XP_038452953.1

EC 2.7.10.1

XP_038452954.1

EC 2.7.10.1

XP_038452955.1

EC 2.7.10.1

XP_038517156.1

EC 2.7.10.1

XP_038517157.1

EC 2.7.10.1

XP_545828.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051807.1 Reference ROS_Cfam_1.0

Range

42203106..42506274

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038661228.1 → XP_038517156.1 insulin-like growth factor 1 receptor isoform X2

UniProtKB/TrEMBL

A0A8C0L611, A0A8C0LVI7, A0A8C0Z5V2, A0A8I3RQ77, A0A8P0ND36

Related

ENSCAFP00845002447.1, ENSCAFT00845003065.1

Conserved Domains (4) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain
XM_038661229.1 → XP_038517157.1 insulin-like growth factor 1 receptor isoform X1

UniProtKB/TrEMBL

A0A8C0TQ22, A0A8C0Z5V2, A0A8I3MER7, A0A8I3RQ77

Related

ENSCAFP00845002481.1, ENSCAFT00845003111.1

Conserved Domains (4) summary

cd05032
Location:969 → 1245

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:812 → 901

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:152 → 307

Furin-like; Furin-like cysteine rich region

pfam01030
Location:329 → 443

Recep_L_domain; Receptor L domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049263.1 Alternate UMICH_Zoey_3.1

Range

41727974..42030799

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038471791.1 → XP_038327719.1 insulin-like growth factor 1 receptor isoform X3

Conserved Domains (4) summary

cd05032
Location:1028 → 1304

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:871 → 960

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:51 → 161

Recep_L_domain; Receptor L domain
XM_038471793.1 → XP_038327721.1 insulin-like growth factor 1 receptor isoform X2

Conserved Domains (4) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain
XM_038471792.1 → XP_038327720.1 insulin-like growth factor 1 receptor isoform X4

Conserved Domains (4) summary

cd05032
Location:1005 → 1281

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:848 → 937

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:152 → 307

Furin-like; Furin-like cysteine rich region

pfam01030
Location:28 → 138

Recep_L_domain; Receptor L domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049744.1 Alternate UNSW_CanFamBas_1.0

Range

41958900..42261698

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038597025.1 → XP_038452953.1 insulin-like growth factor 1 receptor isoform X5

Conserved Domains (4) summary

cd05032
Location:1028 → 1304

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:871 → 960

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:51 → 161

Recep_L_domain; Receptor L domain
XM_038597027.1 → XP_038452955.1 insulin-like growth factor 1 receptor isoform X2

Conserved Domains (4) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain
XM_038597026.1 → XP_038452954.1 insulin-like growth factor 1 receptor isoform X6

Conserved Domains (4) summary

cd05032
Location:1005 → 1281

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:848 → 937

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:152 → 307

Furin-like; Furin-like cysteine rich region

pfam01030
Location:28 → 138

Recep_L_domain; Receptor L domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049224.1 Alternate UU_Cfam_GSD_1.0

Range

42179556..42481580

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038532717.1 → XP_038388645.1 insulin-like growth factor 1 receptor isoform X7

UniProtKB/TrEMBL

A0A8C0M1U9, A0A8C0Z5V2, A0A8I3MMA7, A0A8I3RQ77

Conserved Domains (4) summary

cd05032
Location:1028 → 1304

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:871 → 960

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:51 → 161

Recep_L_domain; Receptor L domain
XM_038532719.1 → XP_038388647.1 insulin-like growth factor 1 receptor isoform X2

UniProtKB/TrEMBL

A0A8C0L611, A0A8C0LVI7, A0A8C0Z5V2, A0A8I3RQ77, A0A8P0ND36

Conserved Domains (4) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain
XM_038532718.1 → XP_038388646.1 insulin-like growth factor 1 receptor isoform X8

UniProtKB/TrEMBL

A0A8C0Z5V2, A0A8I3RQ77

Conserved Domains (4) summary

cd05032
Location:1005 → 1281

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:848 → 937

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:152 → 307

Furin-like; Furin-like cysteine rich region

pfam01030
Location:28 → 138

Recep_L_domain; Receptor L domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

44494039..44797005

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_545828.7 → XP_545828.2 insulin-like growth factor 1 receptor isoform X2

UniProtKB/TrEMBL

A0A8C0L611, A0A8C0LVI7, A0A8C0Z5V2, A0A8I3RQ77, A0A8P0ND36

Conserved Domains (4) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain
XM_014112396.2 → XP_013967871.1 insulin-like growth factor 1 receptor isoform X1

UniProtKB/TrEMBL

A0A8C0TQ22, A0A8C0Z5V2, A0A8I3MER7, A0A8I3RQ77

Conserved Domains (4) summary

cd05032
Location:969 → 1245

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:812 → 901

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:152 → 307

Furin-like; Furin-like cysteine rich region

pfam01030
Location:329 → 443

Recep_L_domain; Receptor L domain