SOCS3 suppressor of cytokine signaling 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SOCS3provided by VGNC
Official Full Name: suppressor of cytokine signaling 3provided by VGNC
Primary source: VGNC:VGNC:46650
See related: Ensembl:ENSCAFG00845014621
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: SOCS-3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (3509383..3512579)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (3516096..3516773)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (3738946..3739623)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (3533406..3534083)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (3657845..3658522)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: suppressor of cytokine signaling 3

Names: cytokine signaling suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031631.1 → NP_001026801.1 suppressor of cytokine signaling 3

See identical proteins and their annotated locations for NP_001026801.1

Status: PROVISIONAL

Source sequence(s)

AB164434

UniProtKB/Swiss-Prot

Q68AM8

Related

ENSCAFP00845020617.1, ENSCAFT00845026155.1

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:184 → 225

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

3509383..3512579

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038674971.1 → XP_038530899.1 suppressor of cytokine signaling 3 isoform X1

UniProtKB/TrEMBL

A0A8C0K1Y3, A0A8C0M019, A0A8I3NU62

Conserved Domains (3) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

COG5178
Location:130 → 162

PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]

cd03737
Location:184 → 225

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...