PTGS2 prostaglandin-endoperoxide synthase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PTGS2provided by VGNC
Official Full Name: prostaglandin-endoperoxide synthase 2provided by VGNC
Primary source: VGNC:VGNC:45152
See related: Ensembl:ENSCAFG00845005378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: COX-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	7	NC_051811.1 (19405501..19412325, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	7	NC_006589.4 (19190741..19197565, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	7	NC_049228.1 (19552954..19559778, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	7	NC_049267.1 (19311510..19318356, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	7	NC_049748.1 (19420827..19427651, complement)

Chromosome 7 - NC_051811.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bradykinin activates PKCepsilon via the PLD/PDK-1 pathway, which subsequently induces activation and translocation of ERK1 into the nucleus, and contributes to COX-2 expression for prostaglandin E2 synthesis in dermal fibroblasts.
Title: Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression.
Increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.
Title: Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade.
These findings demonstrate low renal COX-2 expression in CKD in young dogs, but whether this is correlated with disease pathogenesis remains unclear.
Title: Low expression of cyclooxygenase-2 in chronic kidney disease in young dogs.
These findings suggest that stimulation of MEK/ERK signaling pathway by NF-kappaB activation regulates IL-1beta-induced COX-2 expression and subsequent prostaglandin E2 release in canine dermal fibroblasts.
Title: Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
provide a rationale for further investigation of COX-2 expression in canine lymphoma for prognostic, chemopreventive and chemotherapeutic purposes
Title: Immunohistochemical expression of cyclooxygenase-2 in normal, hyperplastic and neoplastic canine lymphoid tissues.
In canine malignant mammary tumors, high COX-2 expression was associated with tumour size, mitotic index, nuclear grade, histological grade of malignancy and lymph node metastasis.
Title: Concurrent expression of cyclo-oxygenase-2 and epidermal growth factor receptor in canine malignant mammary tumours.
The results suggest that mPGES1 is involved in the regulation of RBF when Na(+) intake is low and that the renal effects elicited by mPGES1 inhibition are modulated by a compensatory increment in PGI2.
Title: Renal effects induced by prolonged mPGES1 inhibition.
The role of COX2 and other angiogenesis-related factors in inflammatory and noninflammatory mammary tumors is reported.
Title: Different role of COX-2 and angiogenesis in canine inflammatory and non-inflammatory mammary cancer.
High cyclooxygenase-2 expression is associated with transitional cell carcinomas.
Title: Molecular imaging of cyclooxygenase-2 in canine transitional cell carcinomas in vitro and in vivo.
Immunoreactivity to COX2 was mainly in the keratinocytes of tumor samples, and it was associated with the presence of inflammation.
Title: Cyclooxygenase-2 is not expressed by canine cutaneous epitheliotropic T-cell lymphoma.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cyclooxygenase pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prostaglandin G/H synthase 2

Names: cyclooxygenase 2; cyclooxygenase type 2; prostaglandin G/H synthase-2

NP_001003354.1

EC 1.14.99.1

XP_038526431.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003354.1 → NP_001003354.1 prostaglandin G/H synthase 2 precursor

See identical proteins and their annotated locations for NP_001003354.1

Status: PROVISIONAL

Source sequence(s)

AY044905

UniProtKB/TrEMBL

A0A8C0QK63, A0A8C0R270, A0A8P0NFH5, Q8SPQ9

Conserved Domains (2) summary

cd09816
Location:75 → 562

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:19 → 54

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051811.1 Reference ROS_Cfam_1.0

Range

19405501..19412325 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038670503.1 → XP_038526431.1 prostaglandin G/H synthase 2 isoform X1

UniProtKB/TrEMBL

A0A8C0QK63, A0A8C0R270, A0A8P0NFH5, Q8SPQ9

Related

ENSCAFP00845007477.1, ENSCAFT00845009561.1

Conserved Domains (2) summary

cd09816
Location:75 → 562

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:19 → 54

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...