NFKB1 nuclear factor kappa B subunit 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NFKB1provided by VGNC
Official Full Name: nuclear factor kappa B subunit 1provided by VGNC
Primary source: VGNC:VGNC:43780
See related: Ensembl:ENSCAFG00845025570
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 32

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	32	NC_051836.1 (24141129..24259888)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	32	NC_006614.4 (17983225..18101473, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	32	NC_049253.1 (15842831..15961478, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	32	NC_049292.1 (24122163..24239736)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	32	NC_049773.1 (23900676..24019275)

Chromosome 32 - NC_051836.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inflammatory response and MAPK and NF-kappaB pathway activation induced by natural street rabies virus infection in the brain tissues of dogs and humans.
Title: Inflammatory response and MAPK and NF-κB pathway activation induced by natural street rabies virus infection in the brain tissues of dogs and humans.
In melanoma cells transfected with siRNA of p65 or p105, IL-1beta-mediated COX-2 mRNA expression was inhibited. These findings suggest that canonical activation of NF-kappaB signaling plays a crucial role for inflammatory states in melanoma cells
Title: NF-κB p65 and p105 implicate in interleukin 1β-mediated COX-2 expression in melanoma cells.
These findings suggest that stimulation of MEK/ERK signaling pathway by NF-kappaB activation regulates IL-1beta-induced COX-2 expression and subsequent prostaglandin E2 release in canine dermal fibroblasts.
Title: Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
The dog p65 and cat p65 subunits of NF-kappaB complementary DNA encoded 542 and 555 amino acids, respectively. The p65 messenger RNA is highly expressed in the dog stomach and cat heart and adipose tissue.
Title: Short communication: molecular characterization of dog and cat p65 subunits of NF-kappaB.
Non-cytotoxic levels of propofol pretreatment can down-regulate LPS-induced inflammatory responses in canine PBMCs, possibly by inhibiting the nuclear translocation of the NF-kappaB p65 protein.
Title: Propofol attenuates LPS-induced tumor necrosis factor-α, interleukin-6 and nitric oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor (NF)-κB activation.
These results suggest that NFkappaB and CAMs may play important roles in the pathogenesis of canine lymphocytic-plasmacytic enteritis.
Title: Activation of nuclear factor-kappa B and cell adhesion molecule mRNA expression in duodenal mucosa of dogs with lymphocytic-plasmacytic enteritis.
The results indicated that activation of NF-kappaB could contribute to the proliferation of neoplastic lymphoid cells, and bortezomib would have suppressive effects on the NF-kappaB activation and the proliferation of neoplastic lymphoid cells in dogs.
Title: Analyses on activation of NF-κB and effect of bortezomib in canine neoplastic lymphoid cell lines.
These data suggest that NOD2 and NFkappaB play an important role in the pathogenesis of LPC.
Title: NOD2 mRNA expression and NFkappaB activation in dogs with lymphocytic plasmacytic colitis.
IGF-1 and PDGF-bb are potent inhibitors of IL-1beta-mediated activation of NF-kappaB and apoptosis in chondrocytes, may be mediated in part through suppression of Src/PI-3K/AKT pathway.
Title: IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nuclear factor NF-kappa-B p105 subunit

Names: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003344.1 → NP_001003344.1 nuclear factor NF-kappa-B p105 subunit

See identical proteins and their annotated locations for NP_001003344.1

Status: PROVISIONAL

Source sequence(s)

AB183419

UniProtKB/Swiss-Prot

F1PM82, Q6F3J0

Related

ENSCAFP00845035432.1, ENSCAFT00845045189.1

Conserved Domains (7) summary

cd07935
Location:42 → 243

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

cd00204
Location:573 → 702

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01177
Location:250 → 351

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:813 → 887

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

pfam12796
Location:583 → 677

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:667 → 723

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:647 → 678

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051836.1 Reference ROS_Cfam_1.0

Range

24141129..24259888

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038443782.1 → XP_038299710.1 nuclear factor NF-kappa-B p105 subunit isoform X1

UniProtKB/Swiss-Prot

F1PM82, Q6F3J0

Conserved Domains (5) summary

cd07935
Location:41 → 242

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

cd01177
Location:249 → 350

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:812 → 886

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:646 → 677

ANK; ANK repeat [structural motif]

pfam12796
Location:582 → 676

Ank_2; Ankyrin repeats (3 copies)
XM_038443783.1 → XP_038299711.1 nuclear factor NF-kappa-B p105 subunit isoform X2

UniProtKB/Swiss-Prot

F1PM82, Q6F3J0

Related

ENSCAFP00845035702.1, ENSCAFT00845045516.1

Conserved Domains (5) summary

cd07935
Location:29 → 230

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

cd01177
Location:237 → 338

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:800 → 874

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

sd00045
Location:634 → 665

ANK; ANK repeat [structural motif]

pfam12796
Location:570 → 664

Ank_2; Ankyrin repeats (3 copies)