CDH1 cadherin 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CDH1provided by VGNC
Official Full Name: cadherin 1provided by VGNC
Primary source: VGNC:VGNC:53314
See related: Ensembl:ENSCAFG00845010704
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: Cadherin-1; Uvomorulin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	5	NC_051809.1 (81192046..81269949, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	5	NC_006587.4 (80748132..80825726, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	5	NC_049226.1 (81341865..81420857, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	5	NC_049265.1 (81019133..81096989, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	5	NC_049746.1 (80702291..80780290, complement)

Chromosome 5 - NC_051809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion.
Title: Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion.
the generation of a shear-induced mechanical event at the shear plane is relayed across the epithelium by actomyosin contraction linked through E-cadherin.
Title: Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion.
Src- and confinement-dependent FAK activation causes E-cadherin relaxation and beta-catenin activity.
Title: Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity.
Results show that cadherin-1 drives type I collagen organization and invadopodia activity in pancreatic ductal adenocarcinoma (PDAC). Also, s significant amount of cadherin-1 remains expressed at the cell surface during tumorigenesis.
Title: Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma.
E-cadherin plays a key role in sensing polarized tensile forces across the tissue and transducing this information to the spindle orientation machinery to align cell divisions.
Title: E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape.
The results show the existence of a softening of the adherens junctional complex in progestagen-dominated stages favoring embryo-maternal interactions and endometrial invasion during canine implantation.
Title: Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium.
ZEB1 appears to not exert E-cadherin transcriptional repression activity
Title: The Relationship Between E-Cadherin and its Transcriptional Repressors in Spontaneously Arising Canine Invasive Micropapillary Mammary Carcinoma.
All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively.
Title: Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors.
Epithelial cells with disrupted E-cadherin gene retain the ability to form cell junctions and apico-basal polarity.
Title: Epithelial DLD-1 Cells with Disrupted E-cadherin Gene Retain the Ability to Form Cell Junctions and Apico-basal Polarity.
the allosteric regulation of cell surface E-cadherin by p120(ctn) dephosphorylation.
Title: Allosteric Regulation of E-Cadherin Adhesion.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cadherin-1

Names: E-cadherin; Epithelial cadherin; cadherin 1, type 1, E-cadherin (epithelial)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287125.2 → NP_001274054.1 cadherin-1 precursor

See identical proteins and their annotated locations for NP_001274054.1

Status: VALIDATED

Source sequence(s)

JAAUVH010000371

UniProtKB/Swiss-Prot

F1PAA9

UniProtKB/TrEMBL

A0A8I3NBM1, A0A8P0SPD4

Related

ENSCAFP00845014829.1, ENSCAFT00845018984.1

Conserved Domains (5) summary

cd00031
Location:160 → 260

CA_like; Cadherin repeat-like domain

cd11304
Location:494 → 593

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:744 → 880

Cadherin_C; Cadherin cytoplasmic region

pfam08758
Location:31 → 120

Cadherin_pro; Cadherin prodomain like

cl09101
Location:608 → 688

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus