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eIF5B eukaryotic translation initiation factor 5B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44261, updated on 4-Apr-2024

Summary

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Official Symbol
eIF5Bprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 5Bprovided by FlyBase
Primary source
FLYBASE:FBgn0026259
Locus tag
Dmel_CG10840
See related
AllianceGenome:FB:FBgn0026259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A1; anon-WO0118547.362; CG10840; CG14970; cIF2; dIF2; Dmel\CG10840; Eif5b; EIF5B; IF2; yIF2
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Is expressed in adult brain cell body rind and adult head. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
63E1-63E1; 3-8 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3428658..3460977, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3428658..3460977, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45737 Neighboring gene sprouty Neighboring gene mir-2282 stem loop Neighboring gene uncharacterized protein Neighboring gene armitage Neighboring gene uncharacterized protein Neighboring gene Cyclin J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa. Linder P, et al. Cell, 2006 Apr 21. PMID 16630807
  2. VASA mediates translation through interaction with a Drosophila yIF2 homolog. Carrera P, et al. Mol Cell, 2000 Jan. PMID 10678180
  3. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article
  4. The DEAD-box helicase Vasa: evidence for a multiplicity of functions in RNA processes and developmental biology. Lasko P. Biochim Biophys Acta, 2013 Aug. PMID 23587717
  5. Interaction with eIF5B is essential for Vasa function during development. Johnstone O, et al. Development, 2004 Sep. PMID 15280213

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. interaction with the general translation factor eIF5B is essential for Vas function during development
    Title: Interaction with eIF5B is essential for Vasa function during development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 5B
Names
CG10840-PB
CG10840-PC
CG10840-PD
CG10840-PE
CG10840-PF
cytoplasmic initiation factor 2
eIF5B-PB
eIF5B-PC
eIF5B-PD
eIF5B-PE
eIF5B-PF
eukaryotic initiation factor 5B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3428658..3460977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259672.2 → NP_001246601.1  eukaryotic translation initiation factor 5B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9ND37, R4TCQ6
    Conserved Domains (5) summary
    cd01887
    Location:557 → 769
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    PRK04004
    Location:553 → 1093
    PRK04004; translation initiation factor IF-2; Validated
    pfam11987
    Location:890 → 993
    IF-2; Translation-initiation factor 2
    cd03703
    Location:779 → 889
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cl02787
    Location:1016 → 1074
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins

  2. NM_001259671.2 → NP_001246600.1  eukaryotic translation initiation factor 5B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246600.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFL1, R4TCQ6
    Conserved Domains (5) summary
    cd01887
    Location:557 → 769
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    pfam00009
    Location:558 → 765
    GTP_EFTU; Elongation factor Tu GTP binding domain
    pfam11987
    Location:890 → 993
    IF-2; Translation-initiation factor 2
    cd03703
    Location:779 → 889
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cl02787
    Location:1016 → 1053
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins

  3. NM_001259670.2 → NP_001246599.1  eukaryotic translation initiation factor 5B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246599.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZP5, R4TCQ6
    Conserved Domains (5) summary
    cd01887
    Location:557 → 769
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    PRK04004
    Location:553 → 1129
    PRK04004; translation initiation factor IF-2; Validated
    pfam11987
    Location:890 → 993
    IF-2; Translation-initiation factor 2
    cd03703
    Location:779 → 889
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cd16266
    Location:1016 → 1110
    IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

  4. NM_001259673.2 → NP_001246602.1  eukaryotic translation initiation factor 5B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246602.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZP5, R4TCQ6
    Conserved Domains (5) summary
    cd01887
    Location:557 → 769
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    PRK04004
    Location:553 → 1129
    PRK04004; translation initiation factor IF-2; Validated
    pfam11987
    Location:890 → 993
    IF-2; Translation-initiation factor 2
    cd03703
    Location:779 → 889
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cd16266
    Location:1016 → 1110
    IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

  5. NM_143717.3 → NP_651974.1  eukaryotic translation initiation factor 5B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZP5, R4TCQ6
    Related
    FBpp0073003
    Conserved Domains (5) summary
    cd01887
    Location:557 → 769
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    PRK04004
    Location:553 → 1129
    PRK04004; translation initiation factor IF-2; Validated
    pfam11987
    Location:890 → 993
    IF-2; Translation-initiation factor 2
    cd03703
    Location:779 → 889
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cd16266
    Location:1016 → 1110
    IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9ND37 M9ND37
M9NFL1 M9NFL1
Q9NJH7 Q9NJH7
Q9VZP5 Q9VZP5

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