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ScpX Sterol carrier protein X-related thiolase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44183, updated on 4-Apr-2024

Summary

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Official Symbol
ScpXprovided by FlyBase
Official Full Name
Sterol carrier protein X-related thiolaseprovided by FlyBase
Primary source
FLYBASE:FBgn0015808
Locus tag
Dmel_CG17320
See related
AllianceGenome:FB:FBgn0015808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17320; Dmel\CG17320
Summary
Predicted to enable phospholipid transporter activity. Predicted to be involved in phospholipid transport and positive regulation of intracellular cholesterol transport. Predicted to be located in peroxisome. Is expressed in several structures, including adult head; embryonic/larval fat body; extended germ band embryo; and gut section. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
37B1-37B1; 2-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18831229..18833630)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18831229..18833630)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 36 member D1 Neighboring gene UDP-glycosyltransferase family 36 member E1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Changes in Drosophila melanogaster midgut proteins in response to dietary Bowman-Birk inhibitor. Li HM, et al. Insect Mol Biol, 2007 Oct. PMID 17725801
  2. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Li HM, et al. Insect Mol Biol, 2010 Jun 1. PMID 20113373
  3. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Yin J, et al. Nat Commun, 2021 Apr 23. PMID 33893307, Free PMC Article
  4. Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model. Erkosar B, et al. FEBS Lett, 2014 Nov 17. PMID 24983497
  5. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetyl-CoA C-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sterol carrier protein X-related thiolase
Names
CG17320-PA
ScpX-PA
sterol carrier protein x
NP_524715.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18831229..18833630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079976.6 → NP_524715.2  sterol carrier protein X-related thiolase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524715.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24506, Q9VJ43
    Related
    FBpp0080659
    Conserved Domains (3) summary
    PRK08256
    Location:5 → 396
    PRK08256; lipid-transfer protein; Provisional
    cd00829
    Location:9 → 395
    SCP-x_thiolase; Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal ...
    pfam02036
    Location:429 → 529
    SCP2; SCP-2 sterol transfer family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24506 Q24506
Q24507 Q24507
Q9VJ43 Q9VJ43

Gene LinkOut

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