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eIF4G1 eukaryotic translation initiation factor 4G1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43839, updated on 11-Apr-2024

Summary

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Official Symbol
eIF4G1provided by FlyBase
Official Full Name
eukaryotic translation initiation factor 4G1provided by FlyBase
Primary source
FLYBASE:FBgn0023213
Locus tag
Dmel_CG10811
See related
AllianceGenome:FB:FBgn0023213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10811; deIF4G; Dmel\CG10811; eiF-4G; eIF-4G; eIF4g; eIF4G; Eif4G; EIF4G; EIF4G1; p200
Summary
Enables RNA 7-methylguanosine cap binding activity and eukaryotic initiation factor 4E binding activity. Involved in regulation of translation and translation. Located in cytosol. Part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including adult head and gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to several human genes including EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
102F1-102F1; 4-0 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (915297..930715, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (935923..951341, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene unc-13 Neighboring gene antisense RNA:CR44029 Neighboring gene pseudo Neighboring gene metabotropic Glutamate Receptor Neighboring gene eIF4E-Transporter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Rissland OS, et al. Genome Biol, 2017 Oct 31. PMID 29089021, Free PMC Article
  2. How strong is the case for regulation of the initiation step of translation by elements at the 3' end of eukaryotic mRNAs? Kozak M. Gene, 2004 Dec 8. PMID 15563830
  3. Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster. Hernández G, et al. Eur J Biochem, 1998 Apr 1. PMID 9578457
  4. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Peter D, et al. Mol Cell, 2015 Mar 19. PMID 25702871
  5. Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression. Nelson MR, et al. EMBO J, 2004 Jan 14. PMID 14685270, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.
    Title: The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
  2. Phosphorylation of 4E-BP1 impairs the competition with eIF4G for eIF4E binding.
    Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.
  3. The eIF4G knockdown did not affect male fertility.
    Title: Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis.
  4. Data show that in the early embryo dFMRP associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.
    Title: dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.
  5. A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.
    Title: A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c916770-916646 mobile_element_type = transposon:INE-1{}2754
  • Loc: c921870-921371 mobile_element_type = transposon:INE-1{}2770
  • Loc: c924378-924020 mobile_element_type = transposon:HB{}5410

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor 4E binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle HMP PubMed 
involved_in translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 4F complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 4G1
Names
CG10811-PA
CG10811-PB
CG10811-PC
Eukaryotic-initiation-factor-4G
eIF-4G
eIF4G1-PA
eIF4G1-PB
eIF4G1-PC
eukaryotic
eukaryotic initiation factor 4G
eukaryotic translation initiation factor 4G
translation initiation factor
translation initiation factor 4G
translation initiation factor eIF4G

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    915297..930715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079901.4 → NP_524640.3  eukaryotic translation initiation factor 4G1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524640.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61380, Q7KQ11
    Conserved Domains (4) summary
    cd11559
    Location:1511 → 1642
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam09606
    Location:1 → 199
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02847
    Location:1309 → 1424
    MA3; MA3 domain
    pfam02854
    Location:751 → 999
    MIF4G; MIF4G domain

  2. NM_001103382.2 → NP_001096852.1  eukaryotic translation initiation factor 4G1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096852.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ29
    Conserved Domains (3) summary
    cd11559
    Location:1764 → 1895
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1562 → 1677
    MA3; MA3 domain
    pfam02854
    Location:1004 → 1252
    MIF4G; MIF4G domain

  3. NM_001144385.2 → NP_001137857.1  eukaryotic translation initiation factor 4G1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61380, Q7KQ11
    Conserved Domains (4) summary
    cd11559
    Location:1511 → 1642
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam09606
    Location:1 → 199
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02847
    Location:1309 → 1424
    MA3; MA3 domain
    pfam02854
    Location:751 → 999
    MIF4G; MIF4G domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DZ29 A8DZ29
O61380 O61380
Q7YU50 Q7YU50

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