N nucleocapsid phosphoprotein [Severe acute respiratory syndrome coronavirus 2] - Gene

Summary

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Gene symbol: N
Gene description: nucleocapsid phosphoprotein
Locus tag: GU280_gp10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage: Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target.
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Genomic context

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Sequence:: NC_045512.2 (28274..29533)

NC_045512.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.
Title: TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA.
Title: The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA.
The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
Title: The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
Assembly of SARS-CoV-2 ribonucleosomes by truncated N[ *] variant of the nucleocapsid protein.
Title: Assembly of SARS-CoV-2 ribonucleosomes by truncated N(∗) variant of the nucleocapsid protein.
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
Title: Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
Title: The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity.
Title: Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity.
Genomic and Temporal Analysis of Deletions Correlated to qRT-PCR Dropout in N Gene in Alpha, Delta and Omicron Variants.
Title: Genomic and Temporal Analysis of Deletions Correlated to qRT-PCR Dropout in N Gene in Alpha, Delta and Omicron Variants.
Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy.
Title: Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy.
TRIM21 promotes ubiquitination of SARS-CoV-2 nucleocapsid protein to regulate innate immunity.
Title: TRIM21 promotes ubiquitination of SARS-CoV-2 nucleocapsid protein to regulate innate immunity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General protein information

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Preferred Names: nucleocapsid phosphoprotein

YP_009724397.2

ORF9; structural protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_045512.2 Reference assembly

Range

28274..29533

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_009724397.2 nucleocapsid phosphoprotein [Severe acute respiratory syndrome coronavirus 2]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P0DTC9

UniProtKB/TrEMBL

A0A6B9VLF5, A0A6B9VNN9, A0A6C0N5E8, A0A6C0T6Z7, A0A6H0C6H8, A0A6H2L7M5, A0A6M3T200, A0A6M6CJY7, A0A6V7AMQ7, A0A6V7AN48, A0A7D5I3X2, A0A7D7P5S6, A0A7H0M5Q1, A0A7S6Z877

Conserved Domains (1) summary

pfam00937
Location:40 → 388

Corona_nucleoca; Coronavirus nucleocapsid protein