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ORF7b ORF7b [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740574, updated on 7-Apr-2024

Summary

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Gene symbol
ORF7b
Gene description
ORF7b
Locus tag
GU280_gp08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF7b encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF7b protein is thought to localize to the Golgi compartment.
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Genomic context

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Sequence:
NC_045512.2 (27756..27887)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene membrane glycoprotein Neighboring gene ORF6 protein Neighboring gene ORF7a protein Neighboring gene ORF8 protein Neighboring gene nucleocapsid phosphoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Bacterial Cell-Based Assay To Study SARS-CoV-2 Protein-Protein Interactions. Springstein BL, et al. mBio, 2021 Dec 21. PMID 34781739, Free PMC Article
  2. Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV-2 replication. Jiang Y, et al. Cell Biosci, 2021 Jul 22. PMID 34294141, Free PMC Article
  3. A new coronavirus associated with human respiratory disease in China. Wu F, et al. Nature, 2020 Mar. PMID 32015508, Free PMC Article
  4. The intraviral protein-protein interaction of SARS-CoV-2 reveals the key role of N protein in virus-like particle assembly. Chen M, et al. Int J Biol Sci, 2021. PMID 34671206, Free PMC Article
  5. A proteome-scale map of the SARS-CoV-2-human contactome. Kim DK, et al. Nat Biotechnol, 2023 Jan. PMID 36217029, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARS-CoV-2 Accessory Protein Orf7b Induces Lung Injury via c-Myc Mediated Apoptosis and Ferroptosis.
    Title: SARS-CoV-2 Accessory Protein Orf7b Induces Lung Injury via c-Myc Mediated Apoptosis and Ferroptosis.
  2. Multiscale Molecular Dynamics Simulations of the Homodimer Accessory Protein ORF7b of SARS-CoV-2.
    Title: Multiscale Molecular Dynamics Simulations of the Homodimer Accessory Protein ORF7b of SARS-CoV-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF7b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    27756..27887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009725318.1 ORF7b [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTD8
    UniProtKB/TrEMBL
    A0A6B9WFL9, A0A6B9WFM6, A0A6C0RQJ7, A0A6M4ETC6, A0A6N1BXP9, A0A7D7H472, A0A7L7W561, A0A7U0EN10, A0A7U0F9N7, A0A7U0IBJ6, A0A7U1M3C6, A0A8B1JMY0, A0A8B1JZS6, A0A8B6RHL2
    Conserved Domains (1) summary
    cd21623
    Location:1 → 43
    ORF7b_SARS-CoV-2; Structural accessory protein ORF7b of Severe Acute Respiratory Syndrome coronavirus 2 and similar proteins
Protein Accession Links
GenPept Link UniProtKB Link
P0DTD8.1 P0DTD8

Gene LinkOut

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