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ORF7a ORF7a protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740573, updated on 7-Apr-2024

Summary

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Gene symbol
ORF7a
Gene description
ORF7a protein
Locus tag
GU280_gp07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF7a encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF7a protein is thought to be a type I transmembrane protein.
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Genomic context

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Sequence:
NC_045512.2 (27394..27759)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene membrane glycoprotein Neighboring gene ORF6 protein Neighboring gene ORF7b Neighboring gene ORF8 protein Neighboring gene nucleocapsid phosphoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes. Pawlica P, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34903581, Free PMC Article
  2. Replication Kinetics of B.1.351 and B.1.1.7 SARS-CoV-2 Variants of Concern Including Assessment of a B.1.1.7 Mutant Carrying a Defective ORF7a Gene. Pyke AT, et al. Viruses, 2021 Jun 7. PMID 34200386, Free PMC Article
  3. Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response. Cao Z, et al. Cell Mol Immunol, 2021 Mar. PMID 33473190, Free PMC Article
  4. Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a. Joonlasak K, et al. Virus Res, 2021 Jan 15. PMID 33227343, Free PMC Article
  5. An 81-Nucleotide Deletion in SARS-CoV-2 ORF7a Identified from Sentinel Surveillance in Arizona (January to March 2020). Holland LA, et al. J Virol, 2020 Jul 1. PMID 32357959, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-kappaB Activation.
    Title: Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation.
  2. SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes.
    Title: SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes.
  3. Replication Kinetics of B.1.351 and B.1.1.7 SARS-CoV-2 Variants of Concern Including Assessment of a B.1.1.7 Mutant Carrying a Defective ORF7a Gene.
    Title: Replication Kinetics of B.1.351 and B.1.1.7 SARS-CoV-2 Variants of Concern Including Assessment of a B.1.1.7 Mutant Carrying a Defective ORF7a Gene.
  4. Functional landscape of SARS-CoV-2 cellular restriction.
    Title: Functional landscape of SARS-CoV-2 cellular restriction.
  5. Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response.
    Title: Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response.
  6. Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion.
    Title: Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion.
  7. Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential.
    Title: Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential.
  8. Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a.
    Title: Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a.
  9. Genomic characterization identified an isolate encoding a 27-amino-acid in-frame deletion in accessory protein ORF7a, the ortholog of SARS-CoV immune antagonist ORF7a/X4.
    Title: An 81-Nucleotide Deletion in SARS-CoV-2 ORF7a Identified from Sentinel Surveillance in Arizona (January to March 2020).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF7a protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    27394..27759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724395.1 ORF7a protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC7
    UniProtKB/TrEMBL
    A0A6B9VSS2, A0A6C0X2S1, A0A6H1PN56, A0A6M4BAG0, A0A6M4N053, A0A6M4N230, A0A6M4NKR9, A0A6M5WP80, A0A6N1CYU7, A0A6N1WG30, A0A6V7AKU4, A0A6V7APJ2, A0A7D5KGX3, A0A7D5NLU8, A0A7D7HDY7, A0A7D7YK76, A0A7H2C638, A0A7H2DQB3, A0A7H4JBK5, A0A7L9VZQ4, A0A7L9W5K4, A0A7L9WA92, A0A7M1HSR1, A0A7M1HUI7, A0A7T6V0A3, A0A7T7T242, A0A7U0MKH4, A0A8B1K8K1, A0A8B1KIC0, A0A8B1L5V5
    Conserved Domains (1) summary
    cd21684
    Location:1 → 121
    ORF7a_SARS-CoV-2-like; Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) structural accessory protein ORF7a and a bat coronavirus (BatCoV RaTG13) from related betacoronaviruses in the subgenera Sarbecovirus (B lineage)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC7.1 P0DTC7

Gene LinkOut

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