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M membrane glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740571, updated on 7-Apr-2024

Summary

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Gene symbol
M
Gene description
membrane glycoprotein
Locus tag
GU280_gp05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The membrane protein is a transmembrane glycoprotein, is the most abundant structural protein in the virus particle and has been suggested as an antiviral drug target.
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Genomic context

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Sequence:
NC_045512.2 (26523..27191)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF3a protein Neighboring gene envelope protein Neighboring gene ORF6 protein Neighboring gene ORF7a protein Neighboring gene ORF7b

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of SARS-CoV-2 M protein in lipid nanodiscs. Dolan KA, et al. Elife, 2022 Oct 20. PMID 36264056, Free PMC Article
  2. SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New Insights. Marques-Pereira C, et al. Int J Mol Sci, 2022 Mar 10. PMID 35328409, Free PMC Article
  3. Active Learning and the Potential of Neural Networks Accelerate Molecular Screening for the Design of a New Molecule Effective against SARS-CoV-2. Yassine R, et al. Biomed Res Int, 2021. PMID 34124259, Free PMC Article
  4. Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications. Shen L, et al. Emerg Microbes Infect, 2021 Dec. PMID 33896413, Free PMC Article
  5. Structure and dynamics of membrane protein in SARS-CoV-2. Mahtarin R, et al. J Biomol Struct Dyn, 2022 Jul. PMID 33353499, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a Myosin Vb Splice Variant and Rab10.
    Title: Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a Myosin Vb Splice Variant and Rab10.
  2. Combination of two rare mutations in the SARS-CoV-2 M gene in patients with severe and prolonged COVID-19.
    Title: Combination of two rare mutations in the SARS-CoV-2 M gene in patients with severe and prolonged COVID-19.
  3. SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK.
    Title: SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK.
  4. Structure and dynamics of membrane protein in SARS-CoV-2.
    Title: Structure and dynamics of membrane protein in SARS-CoV-2.
  5. Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target.
    Title: Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target.
  6. SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New Insights.
    Title: SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New Insights.
  7. Immunodominant linear B cell epitopes in the spike and membrane proteins of SARS-CoV-2 identified by immunoinformatics prediction and immunoassay.
    Title: Immunodominant linear B cell epitopes in the spike and membrane proteins of SARS-CoV-2 identified by immunoinformatics prediction and immunoassay.
  8. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
    Title: Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
  9. Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease.
    Title: Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease.
  10. Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications.
    Title: Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
membrane glycoprotein
YP_009724393.1
  • ORF5; structural protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    26523..27191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724393.1 membrane glycoprotein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC5
    UniProtKB/TrEMBL
    A0A6B9VLF3, A0A6C0NA72, A0A6H1PIT3, A0A6H2LA17, A0A6M3HU26, A0A6M4EMV2, A0A6M4MMC8, A0A6M4MNT4, A0A6M4NGH5, A0A6M5CDR3, A0A6N1P5D3, A0A6V7AL93, A0A6V7ANW8, A0A7D5I222, A0A7D5JUK8, A0A7G5WJL3, A0A7H0C2Z5, A0A7H2DS47, A0A7L9CEB1, A0A7S5YI14, A0A7U1DAY2, A0A7U1Q5G9, A0A7U2GRH6, A0A7U3EF99, A0A7U3HGG8, A0A894PC32, A0A899KD10, A0A8B1GS46, A0A8B1LT55
    Conserved Domains (1) summary
    cd21569
    Location:5 → 222
    SARS-like-CoV_M; Membrane (or Matrix) protein from Severe acute respiratory syndrome (SARS) coronavirus, SARS-CoV-2, and related betacoronaviruses in the B lineage
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC5.1 P0DTC5

Gene LinkOut

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