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eEF1alpha2 eukaryotic translation elongation factor 1 alpha 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43736, updated on 4-Apr-2024

Summary

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Official Symbol
eEF1alpha2provided by FlyBase
Official Full Name
eukaryotic translation elongation factor 1 alpha 2provided by FlyBase
Primary source
FLYBASE:FBgn0000557
Locus tag
Dmel_CG1873
See related
AllianceGenome:FB:FBgn0000557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1873; Dmel\CG1873; eEF1; eEF1alpha; EF-1; ef-1alpha; EF-1alpha; EF-1alpha F2; Ef1 alpha100E; EF1-a 100E; EF1-alpha; EF1a; EF1A; Ef1a-100E; Ef1a48; EF1alpha; EF1alpha100; Ef1alpha100E; Ef1alpha2; Efla2; F2
Summary
Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
100D2-100D2; 3-102 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31738468..31743306)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27564190..27569028)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cleavage stimulation factor 50 kD subunit Neighboring gene uncharacterized protein Neighboring gene Tubulin binding cofactor A Neighboring gene uncharacterized protein Neighboring gene abnormal wing discs

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. F1 and F2: Two similar genes regulated differently during development of Drosophila melanogaster. Walldorf U, et al. Proc Natl Acad Sci U S A, 1985 Sep. PMID 16593598, Free PMC Article
  2. The expression of the EF1 alpha genes of Drosophila is not associated with the extended longevity phenotype in a selected long-lived strain. Dudas SP, et al. Exp Gerontol, 1994 Nov-Dec. PMID 9435916
  3. Genetic analysis of mechanisms of aging. Rose MR, et al. Curr Opin Genet Dev, 1996 Jun. PMID 8791514
  4. Genetics of aging: current animal models. Shmookler Reis RJ, et al. Exp Gerontol, 1996 Jan-Apr. PMID 8706806
  5. Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Shepherd JC, et al. Proc Natl Acad Sci U S A, 1989 Oct. PMID 2508089, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of eukaryotic translation elongation factor 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation elongation factor 1 alpha 2
Names
CG1873-PA
CG1873-PB
CG1873-PC
CG1873-PD
ELONGATION FACTOR 1-ALPHA 2
S
eEF1alpha2-PA
eEF1alpha2-PB
eEF1alpha2-PC
eEF1alpha2-PD
elongation factor 1-alpha
elongation factor 1-alpha F2
elongation factor 1alpha 100E
elongation factor 1alpha100E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31738468..31743306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079872.4 → NP_524611.1  eukaryotic translation elongation factor 1 alpha 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524611.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05303, Q9V9U8
    UniProtKB/TrEMBL
    A4V3Q6
    Related
    FBpp0085193, FBtr0085832
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 450
    PTZ00141; elongation factor 1- alpha; Provisional

  2. NM_206592.1 → NP_996315.1  eukaryotic translation elongation factor 1 alpha 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996315.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05303, Q9V9U8
    UniProtKB/TrEMBL
    A4V3Q6
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 450
    PTZ00141; elongation factor 1- alpha; Provisional

  3. NM_170570.1 → NP_733449.1  eukaryotic translation elongation factor 1 alpha 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733449.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05303, Q9V9U8
    UniProtKB/TrEMBL
    A4V3Q6
    Related
    FBpp0085194, FBtr0085833
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 450
    PTZ00141; elongation factor 1- alpha; Provisional

  4. NM_206593.1 → NP_996316.1  eukaryotic translation elongation factor 1 alpha 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996316.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05303, Q9V9U8
    UniProtKB/TrEMBL
    A4V3Q6
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 450
    PTZ00141; elongation factor 1- alpha; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V3Q6 A4V3Q6
P05303.2 P05303

Gene LinkOut

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