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CstF50 Cleavage stimulation factor 50 kD subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43734, updated on 10-May-2024

Summary

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Official Symbol
CstF50provided by FlyBase
Official Full Name
Cleavage stimulation factor 50 kD subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0039867
Locus tag
Dmel_CG2261
See related
AllianceGenome:FB:FBgn0039867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2261; CstF-50; Dmel\CG2261
Summary
Located in nucleoplasm. Part of mRNA cleavage stimulating factor complex. Is expressed in organism. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
100D1-100D1; 3-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31735503..31736963, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27561225..27562685, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR34046 Neighboring gene tramtrack Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation elongation factor 1 alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hexameric architecture of CstF supported by CstF-50 homodimerization domain structure. Moreno-Morcillo M, et al. RNA, 2011 Mar. PMID 21233223, Free PMC Article
  2. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Sullivan KD, et al. Mol Cell, 2009 May 15. PMID 19450530, Free PMC Article
  3. Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript. Zhang Z, et al. Mol Cell, 2006 Jan 6. PMID 16387654
  4. P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo. Ni Z, et al. Mol Cell Biol, 2008 Feb. PMID 18070927, Free PMC Article
  5. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage stimulating factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage stimulating factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage stimulating factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cleavage stimulation factor 50 kD subunit
Names
CG2261-PA
CstF-50
CstF50-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31735503..31736963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143626.3 → NP_651883.1  cleavage stimulation factor 50 kD subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651883.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9V0
    Related
    FBpp0085224
    Conserved Domains (3) summary
    cd00200
    Location:98 → 417
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:113 → 164
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:10 → 63
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9V0 Q9V9V0

Gene LinkOut

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