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rac3a Rac family small GTPase 3a [ Danio rerio (zebrafish) ]

Gene ID: 437027, updated on 27-Mar-2024

Summary

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Official Symbol
rac3aprovided by ZNC
Official Full Name
Rac family small GTPase 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-256
See related
Ensembl:ENSDARG00000090062 AllianceGenome:ZFIN:ZDB-GENE-040718-256
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rac3; wu:fb95b01; zgc:100831
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and neuron projection. Is expressed in blastomere; hatching gland; nervous system; somite; and trigeminal placode. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 3
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36248851..36259930, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36119119..36130332, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene G protein pathway suppressor 1 Neighboring gene protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a Neighboring gene zgc:86896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rac2 expression and its role in neutrophil functions of zebrafish (Danio rerio). Tell RM, et al. Fish Shellfish Immunol, 2012 Nov. PMID 22992407
  2. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014 Sep. PMID 24722243, Free PMC Article
  3. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, et al. J Immunol, 2016 Dec 15. PMID 27837107, Free PMC Article
  4. Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Lu Y, et al. Front Mol Neurosci, 2022. PMID 35600071, Free PMC Article
  5. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related C3 botulinum toxin substrate 3a
Names
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
ras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3)
NP_001002754.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002754.2 → NP_001002754.1  ras-related C3 botulinum toxin substrate 3a

    See identical proteins and their annotated locations for NP_001002754.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076433
    UniProtKB/TrEMBL
    A0A8M1N111, Q6DGB7
    Related
    ENSDARP00000111723.2, ENSDART00000126588.3
    Conserved Domains (1) summary
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    36248851..36259930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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