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ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon [ Danio rerio (zebrafish) ]

Gene ID: 437024, updated on 19-Jan-2025

Summary

Official Symbol
ikbkeprovided by ZNC
Official Full Name
inhibitor of nuclear factor kappa B kinase subunit epsilonprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-251
See related
Ensembl:ENSDARG00000070606 AllianceGenome:ZFIN:ZDB-GENE-040718-251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:100844
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in activation of innate immune response and positive regulation of type I interferon production. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See ikbke in Genome Data Viewer
Location:
chromosome: 11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (21364605..21404040, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (21204517..21243626, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene Ras association domain family member 5 Neighboring gene uncharacterized LOC137490705 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene zgc:101564

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables IkappaB kinase activity  
enables kinase activity  
enables nucleotide binding  
enables protein kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables transferase activity  
Component Evidence Code Pubs
is_active_in cytoplasm  

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Names
IKKe
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NP_001002751.1
XP_005172929.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002751.2NP_001002751.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon

    See identical proteins and their annotated locations for NP_001002751.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076405
    UniProtKB/TrEMBL
    Q6DGE5
    Related
    ENSDARP00000074566.4, ENSDART00000080116.6
    Conserved Domains (3) summary
    smart00220
    Location:9243
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl00155
    Location:298386
    UBQ; Ubiquitin-like proteins
    cl21453
    Location:15327
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    21364605..21404040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172872.5XP_005172929.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

    UniProtKB/TrEMBL
    A0A8M2BK50, F1QBC9
    Related
    ENSDARP00000106309.1, ENSDART00000129062.3
    Conserved Domains (3) summary
    smart00220
    Location:9243
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl00155
    Location:298386
    UBQ; Ubiquitin-like proteins
    cl21453
    Location:15327
    PKc_like; Protein Kinases, catalytic domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394817.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    200890..238327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395300.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    60006..97442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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