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camk2d2 calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 [ Danio rerio (zebrafish) ]

Gene ID: 436815, updated on 27-Mar-2024

Summary

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Official Symbol
camk2d2provided by ZNC
Official Full Name
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-277
See related
Ensembl:ENSDARG00000014273 AllianceGenome:ZFIN:ZDB-GENE-040718-277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
camk2d; camk2da; zgc:92792; wu:fq17a12
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and neuron projection. Is expressed in nervous system; neural rod; neural tube; and trunk. Orthologous to human CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 1
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (14162472..14234120, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (13475959..13547615, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene histone PARylation factor 1 Neighboring gene ankyrin 2a, neuronal Neighboring gene uncharacterized LOC101887098 Neighboring gene chemokine (C-X-C motif) ligand 8a Neighboring gene phosphodiesterase 5A, cGMP-specific, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. Sitaraman S, et al. Elife, 2021 Aug 4. PMID 34346310, Free PMC Article
  2. Genetic compensation of γ CaMKII, an evolutionarily conserved gene. Rothschild SC, et al. Gene, 2020 Jun 5. PMID 32165308
  3. NMDA receptors on zebrafish Mauthner cells require CaMKII-α for normal development. Roy B, et al. Dev Neurobiol, 2015 Feb. PMID 25047640
  4. Differential expression of CaMK-II genes during early zebrafish embryogenesis. Rothschild SC, et al. Dev Dyn, 2007 Jan. PMID 17103413
  5. Chromatin signature of embryonic pluripotency is established during genome activation. Vastenhouw NL, et al. Nature, 2010 Apr 8. PMID 20336069, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type II delta 2 chain
Names
caM kinase II subunit delta-A
caM-kinase II delta-A chain
caMK-II subunit delta-A
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta a
calcium/calmodulin-dependent protein kinase type II delta-A chain
NP_001002542.1
XP_005159893.1
XP_009304932.1
XP_009304936.1
XP_009304937.1
XP_009304938.1
XP_009304940.1
XP_009304942.1
XP_009304944.1
XP_017209507.1
XP_017209573.1
XP_021327037.1
XP_021327221.1
XP_021327262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002542.1 → NP_001002542.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain

    See identical proteins and their annotated locations for NP_001002542.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076266
    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    Related
    ENSDARP00000040048.6, ENSDART00000040049.7
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:361 → 488
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    14162472..14234120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306663.3 → XP_009304938.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X6

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3AYD5
    Conserved Domains (3) summary
    smart00220
    Location:13 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:401 → 528
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_009306661.3 → XP_009304936.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X3

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3B7E7
    Conserved Domains (3) summary
    smart00220
    Location:13 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:421 → 548
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. XM_009306662.3 → XP_009304937.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X5

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3B4L7
    Conserved Domains (3) summary
    smart00220
    Location:13 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:402 → 529
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  4. XM_021471362.1 → XP_021327037.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X4

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M9P897
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:415 → 542
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  5. XM_017354018.2 → XP_017209507.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M6YWG3

  6. XM_009306667.3 → XP_009304942.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X8

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3B7F4
    Conserved Domains (3) summary
    smart00220
    Location:13 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:387 → 514
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  7. XM_021471546.1 → XP_021327221.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X11

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M9PY32
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:368 → 495
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  8. XM_009306669.3 → XP_009304944.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X9

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3AYD9
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:381 → 508
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  9. XM_009306665.3 → XP_009304940.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X7

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3AYB7
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:388 → 515
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  10. XM_005159836.4 → XP_005159893.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X12

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M2B6H3
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360 → 487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  11. XM_017354084.2 → XP_017209573.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X10

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M6YVY0
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380 → 507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  12. XM_009306657.3 → XP_009304932.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X2

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M3AYA9, F1QGL7
    Related
    ENSDARP00000044895.7, ENSDART00000044896.9
    Conserved Domains (3) summary
    smart00220
    Location:13 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:422 → 549
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  13. XM_021471587.1 → XP_021327262.1  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X13

    UniProtKB/Swiss-Prot
    A8WGM2, Q6DGS3
    UniProtKB/TrEMBL
    A0A8M9P8T6
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380 → 507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGS3.2 GenPept UniProtKB/Swiss-Prot:Q6DGS3

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