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Tpi Triose phosphate isomerase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43582, updated on 10-May-2024

Summary

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Official Symbol
Tpiprovided by FlyBase
Official Full Name
Triose phosphate isomeraseprovided by FlyBase
Primary source
FLYBASE:FBgn0086355
Locus tag
Dmel_CG2171
See related
AllianceGenome:FB:FBgn0086355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2171; Dmel\CG2171; ND14; sgk; tpi; TPI; TPIS; wstd
Summary
Enables protein homodimerization activity and triose-phosphate isomerase activity. Involved in several processes, including determination of adult lifespan; glucose homeostasis; and glycolytic process. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; muscle system; spermatozoon; and wing disc. Used to study neurodegenerative disease and triosephosphate isomerase deficiency. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
99D8-99D8; 3-100 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30132981..30134599, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25958703..25960321, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 1c interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46082 Neighboring gene Adenosine receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster. Stone A, et al. Front Synaptic Neurosci, 2023. PMID 36926383, Free PMC Article
  2. Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo. Roland BP, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Sep 1. PMID 31075491, Free PMC Article
  3. Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency. Roland BP, et al. Biochim Biophys Acta, 2015 Jan. PMID 25463631, Free PMC Article
  4. Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity. Roland BP, et al. J Cell Sci, 2013 Jul 15. PMID 23641070, Free PMC Article
  5. Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency. Hrizo SL, et al. Neurobiol Dis, 2013 Jun. PMID 23318931, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings are the first to identify, to our knowledge, a functional synaptic defect in TPI deficiency derived from molecular changes in the TPI dimer interface.
    Title: Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.
  2. TPI sugarkill can be genetically complemented by TPI encoding a catalytically inactive enzyme.
    Title: Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.
  3. Mutation of wasted away, a recessive, hypomorphic mutation of triosephosphate isomerase (Tpi), highlights the essential protective role of triosephosphate isomerase.
    Title: wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triose-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triose-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triose-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables triose-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables triose-phosphate isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glyceraldehyde-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyceraldehyde-3-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
triose phosphate isomerase
Names
CG2171-PA
CG2171-PB
CG2171-PC
Tpi-PA
Tpi-PB
Tpi-PC
neurodegeneration 14
sugarkill
triosephosphate isomerase
wasted away
NP_788764.1
NP_788765.1
NP_788766.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30132981..30134599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176587.2 → NP_788764.1  triose phosphate isomerase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788764.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29613
    Related
    FBpp0084948
    Conserved Domains (1) summary
    PTZ00333
    Location:102 → 346
    PTZ00333; triosephosphate isomerase; Provisional

  2. NM_176588.2 → NP_788765.1  triose phosphate isomerase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788765.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76995, P29613, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56
    Related
    FBpp0084949
    Conserved Domains (1) summary
    PTZ00333
    Location:1 → 245
    PTZ00333; triosephosphate isomerase; Provisional

  3. NM_176589.2 → NP_788766.1  triose phosphate isomerase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76995, P29613, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56
    Related
    FBpp0084950
    Conserved Domains (1) summary
    PTZ00333
    Location:1 → 245
    PTZ00333; triosephosphate isomerase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29613.3 P29613

Gene LinkOut

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