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Rpn2 Regulatory particle non-ATPase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43449, updated on 5-May-2024

Summary

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Official Symbol
Rpn2provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 2provided by FlyBase
Primary source
FLYBASE:FBgn0028692
Locus tag
Dmel_CG11888
See related
AllianceGenome:FB:FBgn0028692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11888; CG11888; Dmel\CG11888; dRpn2; p110; PSMC1; rpn2; RPN2; S1
Summary
Enables zinc ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including adult heart; embryonic brain; extended germ band embryo; larval ventral nerve cord; and spermatozoon. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
98F13-98F13; 3-97 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29153524..29157255)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24979246..24982977)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phosphoglyceromutase 78 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene Stem-loop binding protein Neighboring gene red dog mine Neighboring gene uncharacterized protein Neighboring gene julius seizure

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression. Sullivan E, et al. Genes Dev, 2001 Jan 15. PMID 11157774, Free PMC Article
  2. The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila. Wong KKL, et al. Proc Natl Acad Sci U S A, 2020 Jan 28. PMID 31932432, Free PMC Article
  3. Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms. Velentzas AD, et al. Sci Rep, 2020 Mar 25. PMID 32214222, Free PMC Article
  4. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Tonoki A, et al. Mol Cell Biol, 2009 Feb. PMID 19075009, Free PMC Article
  5. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain C, et al. J Biol Chem, 2004 Aug 27. PMID 15210720

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
regulatory particle non-ATPase 2
Names
CG11888-PA
CG11888-PB
CG11888-PC
Rpn2-PA
Rpn2-PB
Rpn2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29153524..29157255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276129.1 → NP_001263058.1  regulatory particle non-ATPase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIH8, Q8IGU4, Q8T075, Q9GSE5, Q9GU70, Q9V3P6
    UniProtKB/TrEMBL
    A0A0B4KHE9
    Conserved Domains (3) summary
    COG5116
    Location:1 → 1003
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01851
    Location:666 → 701
    PC_rep; Proteasome/cyclosome repeat
    sd00044
    Location:616 → 639
    HEAT; HEAT repeat [structural motif]

  2. NM_143420.3 → NP_651677.2  regulatory particle non-ATPase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651677.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIH8, Q8IGU4, Q8T075, Q9GSE5, Q9GU70, Q9V3P6
    UniProtKB/TrEMBL
    A0A0B4KHE9
    Related
    FBpp0084754
    Conserved Domains (3) summary
    COG5116
    Location:1 → 1003
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01851
    Location:666 → 701
    PC_rep; Proteasome/cyclosome repeat
    sd00044
    Location:616 → 639
    HEAT; HEAT repeat [structural motif]

  3. NM_001276128.1 → NP_001263057.1  regulatory particle non-ATPase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263057.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI10
    Conserved Domains (3) summary
    COG5116
    Location:1 → 1003
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01851
    Location:666 → 701
    PC_rep; Proteasome/cyclosome repeat
    sd00044
    Location:616 → 639
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHE9 A0A0B4KHE9
A0A0B4KI10 A0A0B4KI10
Q9V3P6.1 Q9V3P6

Gene LinkOut

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