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Cpsf100 Cleavage and polyadenylation specificity factor 100 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43426, updated on 10-May-2024

Summary

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Official Symbol
Cpsf100provided by FlyBase
Official Full Name
Cleavage and polyadenylation specificity factor 100provided by FlyBase
Primary source
FLYBASE:FBgn0027873
Locus tag
Dmel_CG1957
See related
AllianceGenome:FB:FBgn0027873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD14168; CG1957; CPSF-100; CPSF100; Dmel\CG1957
Summary
Predicted to enable RNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA polyadenylation. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic brain; embryonic/larval midgut; and extended germ band embryo. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
98F5-98F5; 3-97 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29034573..29037062)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24860295..24862784)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45044 Neighboring gene beta1,4-N-acetylgalactosaminyltransferase B Neighboring gene Strictosidine synthase-like 2 Neighboring gene Slu7 Neighboring gene Protein C kinase 98E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. Michalski D, et al. RNA, 2015 Aug. PMID 26081560, Free PMC Article
  2. Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations. Harrington AW, et al. BMC Genomics, 2017 Apr 17. PMID 28415970, Free PMC Article
  3. Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Skrajna A, et al. Nucleic Acids Res, 2018 May 18. PMID 29529248, Free PMC Article
  4. U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein. Skrajna A, et al. RNA, 2017 Jun. PMID 28289156, Free PMC Article
  5. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Sullivan KD, et al. Mol Cell, 2009 May 15. PMID 19450530, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cleavage and polyadenylation specificity factor 100
Names
CG1957-PA
Cpsf100-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29034573..29037062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143401.3 → NP_651658.1  cleavage and polyadenylation specificity factor 100 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651658.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IML7, Q9V3D6
    Related
    FBpp0084726
    Conserved Domains (5) summary
    smart01027
    Location:243 → 369
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:19 → 400
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:538 → 577
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    pfam13299
    Location:617 → 753
    CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
    cd16293
    Location:7 → 204
    CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3D6.1 Q9V3D6

Gene LinkOut

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