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PolA2 DNA polymerase alpha subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43278, updated on 4-Apr-2024

Summary

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Official Symbol
PolA2provided by FlyBase
Official Full Name
DNA polymerase alpha subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0005696
Locus tag
Dmel_CG5923
See related
AllianceGenome:FB:FBgn0005696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5923; Dmel\CG5923; Dmpol alpha; DNA pol-73; DNA polalpha; DNA polymerase alpha 73 kD; DNApol-alpha; DNApol-alpha72; DNApol-alpha73; DNApolalpha; Pol; pol alpha; POLA; polalpha; Polalpha; Polalpha 73kDa; Polalpha 73KDa; Polalpha73
Summary
Predicted to enable DNA binding activity. Involved in DNA-dependent DNA replication. Part of alpha DNA polymerase:primase complex. Is expressed in female pronucleus and male pronucleus. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
97E10-97E10; 3-92 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27239163..27241228)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23064885..23066950)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation and dephosphorylation of the B subunit of DNA polymerase alpha-primase complex in the early embryogenesis of Drosophila. Kuroda K, et al. Biochem Biophys Res Commun, 1999 Jan 19. PMID 9918845
  2. Cloning of the gene for the 73 kD subunit of the DNA polymerase alpha primase of Drosophila melanogaster. Cotterill S, et al. Nucleic Acids Res, 1992 Aug 25. PMID 1508723, Free PMC Article
  3. A 130 kDa polypeptide immunologically related to the 180 kDa catalytic subunit of DNA polymerase alpha-primase complex is detected in early embryos of Drosophila. Kuroda K, et al. J Biochem, 1995 Apr. PMID 7592543
  4. Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster. Sasaki T, et al. Mol Cell Biol, 1999 Jan. PMID 9858578, Free PMC Article
  5. Recollections of a DNA enzymologist. Lehman IR. Protein Sci, 1998 Apr. PMID 9568914, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of alpha DNA polymerase:primase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DNA polymerase alpha subunit 2
Names
B subunit
CG5923-PC
DNA polymerase 73K
DNA polymerase alpha
DNA polymerase alpha 73,000 alpha subunit
DNA polymerase alpha 73kD
DNA polymerase alpha 73kD subunit
DNA polymerase alpha primase 73 kda subunit
DNA-polymerase alpha
DNApol-alpha73
PolA2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27239163..27241228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170327.4 → NP_733206.3  DNA polymerase alpha subunit 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733206.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95S59, Q9TXB0, Q9VB62
    UniProtKB/TrEMBL
    T2GG50
    Conserved Domains (2) summary
    pfam04042
    Location:363 → 561
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:18 → 180
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB62.2 Q9VB62

Gene LinkOut

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