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Nrg2 neuregulin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 432361, updated on 13-Apr-2024

Summary

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Symbol
Nrg2provided by RGD
Full Name
neuregulin 2provided by RGD
Primary source
RGD:1303302
See related
Ensembl:ENSRNOG00000019093 AllianceGenome:RGD:1303302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ntak; NTAK alpha1; NTAK alpha2a; NTAK_alpha2a
Summary
Enables ErbB-3 class receptor binding activity; epidermal growth factor receptor binding activity; and epidermal growth factor-activated receptor activity. Involved in epidermal growth factor receptor signaling pathway; regulation of synapse assembly; and regulation of synapse maturation. Is active in GABA-ergic synapse and glutamatergic synapse. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 25.7), Lung (RPKM 23.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nrg2 in Genome Data Viewer
Location:
18p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27890578..28072538, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27616542..27798505, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28835391..29015552, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551758 Neighboring gene uncharacterized LOC134483009 Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene uncharacterized LOC120098187 Neighboring gene purine rich element binding protein A Neighboring gene IgA-inducing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release by ADAM10 [corrected]. Vullhorst D, et al. Mol Neurobiol, 2019 Dec. PMID 31240601, Free PMC Article
  2. Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus. Lee KH, et al. J Neurosci, 2015 Dec 16. PMID 26674872, Free PMC Article
  3. Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression. Ponomareva ON, et al. Glia, 2006 Nov 1. PMID 16944454
  4. NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3. Nakano N, et al. Neurosci Lett, 2016 May 27. PMID 27113200
  5. Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons. Longart M, et al. J Comp Neurol, 2004 Apr 26. PMID 15048684

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NRG2 and Kv2.1 are co-regulated components of a shared pathway that responds to elevated extracellular glutamate levels.
    Title: NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release by ADAM10 [corrected].
  2. NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro.
    Title: NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.
  3. These results imply that NRG2 may play a critical role in network integration of newborn neurons
    Title: Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus.
  4. Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
    Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
  5. These results provide a potential role for the previously reported, paradoxical perisynaptic accumulation of Nrg-2alpha, the isoform with the least AChR-inducing activity when presented in a soluble form.
    Title: Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression.
  6. In neuronal primary cultures from developing rat hippocampus, neuregulin 2 (NRG-2) is restricted to neuronal somas and dendrites.
    Title: Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ErbB-3 class receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ErbB-4 class receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables epidermal growth factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERBB4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERBB4-ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pro-neuregulin-2, membrane-bound isoform
Names
neural- and thymus-derived activator for ErbB kinases
pro-NRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136151.2 → NP_001129623.2  pro-neuregulin-2, membrane-bound isoform

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6GKI5, D4A078
    Related
    ENSRNOP00000028713.7, ENSRNOT00000028713.8
    Conserved Domains (2) summary
    smart00409
    Location:259 → 344
    IG; Immunoglobulin
    cd00054
    Location:369 → 397
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27890578..28072538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277502.1 → XP_063133572.1  pro-neuregulin-2, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A8I6A510

  2. XM_063277501.1 → XP_063133571.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHJ7

  3. XM_063277503.1 → XP_063133573.1  pro-neuregulin-2, membrane-bound isoform isoform X3

  4. XM_063277504.1 → XP_063133574.1  pro-neuregulin-2, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    F1LM11

  5. XM_063277506.1 → XP_063133576.1  pro-neuregulin-2, membrane-bound isoform isoform X6

  6. XM_063277505.1 → XP_063133575.1  pro-neuregulin-2, membrane-bound isoform isoform X5

  7. XM_063277507.1 → XP_063133577.1  pro-neuregulin-2, membrane-bound isoform isoform X7

  8. XM_063277508.1 → XP_063133578.1  pro-neuregulin-2, membrane-bound isoform isoform X8

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35569.1 GenPept UniProtKB/Swiss-Prot:O35569

Gene LinkOut

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