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MMP10 matrix metallopeptidase 10 [ Homo sapiens (human) ]

Gene ID: 4319, updated on 5-Mar-2024

Summary

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Official Symbol
MMP10provided by HGNC
Official Full Name
matrix metallopeptidase 10provided by HGNC
Primary source
HGNC:HGNC:7156
See related
Ensembl:ENSG00000166670 MIM:185260; AllianceGenome:HGNC:7156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SL-2; STMY2
Summary
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward endometrium (RPKM 266.6) See more
Orthologs
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Genomic context

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See MMP10 in Genome Data Viewer
Location:
11q22.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (102770502..102780628, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (102774317..102784440, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102641233..102651359, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:102594892-102596091 Neighboring gene matrix metallopeptidase 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102617370-102617934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102617935-102618499 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:102623204-102624403 Neighboring gene sacsin molecular chaperone pseudogene Neighboring gene WTAP pseudogene 1 Neighboring gene matrix metallopeptidase 1 Neighboring gene casein kinase 1 alpha 1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type. Martino Adami PV, et al. Brain, 2022 Jul 29. PMID 35088840
  2. MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study. Wu LN, et al. J Stroke Cerebrovasc Dis, 2021 Oct. PMID 34418671
  3. Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling. Hu C, et al. Cell Death Dis, 2021 Jan 12. PMID 33436543, Free PMC Article
  4. A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis. Matilla L, et al. Arterioscler Thromb Vasc Biol, 2020 May. PMID 32188274
  5. MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade. Mora-Gutiérrez JM, et al. Sci Rep, 2020 Jan 8. PMID 31913319, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFkappaBeta pathway inhibition.
    Title: Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition.
  2. The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility.
    Title: The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility.
  3. Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma.
    Title: Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma.
  4. Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10.
    Title: Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10.
  5. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type.
    Title: Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type.
  6. MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression.
    Title: MicroRNA-152 Regulates Endometrial Serous Carcinoma Cell Motility by Suppressing Matrix Metalloproteinase 10 Expression.
  7. Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
    Title: Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
  8. miR-496/MMP10 Is Involved in the Proliferation of IL-1beta-Induced Fibroblast-Like Synoviocytes Via Mediating the NF-kappaB Signaling Pathway.
    Title: miR-496/MMP10 Is Involved in the Proliferation of IL-1β-Induced Fibroblast-Like Synoviocytes Via Mediating the NF-κB Signaling Pathway.
  9. Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
    Title: Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
  10. MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study.
    Title: MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study.
Submit: New GeneRIF Correction See all GeneRIFs (88)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of brain lesion distribution in multiple sclerosis.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of matrix metallopeptidase 10 (MMP10; stromelysin 2) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity TAS
Traceable Author Statement
more info
  
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in collagen catabolic process TAS
Traceable Author Statement
more info
  
involved_in extracellular matrix disassembly TAS
Traceable Author Statement
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stromelysin-2
Names
MMP-10
matrix metalloprotease 10
matrix metalloproteinase 10 (stromelysin 2)
matrix metalloproteinase-10
transin 2
NP_002416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002425.3 → NP_002416.1  stromelysin-2 preproprotein

    See identical proteins and their annotated locations for NP_002416.1

    Status: REVIEWED

    Source sequence(s)
    AK313960, BC002591
    Consensus CDS
    CCDS8321.1
    UniProtKB/Swiss-Prot
    B2R9X9, P09238, Q53HH9
    Related
    ENSP00000279441.4, ENST00000279441.9
    Conserved Domains (3) summary
    cd00094
    Location:286 → 476
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:107 → 263
    Peptidase_M10; Matrixin
    pfam01471
    Location:33 → 86
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    102770502..102780628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    102774317..102784440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09238.1 GenPept UniProtKB/Swiss-Prot:P09238

Gene LinkOut

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