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PNPLA2 patatin like phospholipase domain containing 2 [ Gallus gallus (chicken) ]

Gene ID: 431066, updated on 3-Apr-2024

Summary

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Symbol
PNPLA2provided by CGNC
Full Name
patatin like phospholipase domain containing 2provided by CGNC
Primary source
CGNC:10816
See related
Ensembl:ENSGALG00010026898
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ATGL
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (15350110..15376279, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (15320307..15346486, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit L Neighboring gene CD151 molecule Neighboring gene EF-hand calcium binding domain 4B Neighboring gene small nucleolar RNA SNORA52 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene leucine rich repeat containing 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of adipose triglyceride lipase by fasting and refeeding in avian species. Serr J, et al. Poult Sci, 2009 Dec. PMID 19903957
  2. cDNA cloning, characterization, and variation analysis of chicken adipose triglyceride lipase (ATGL) gene. Nie Q, et al. Mol Cell Biochem, 2009 Jan. PMID 18679582
  3. Identification and characterization of adipose triglyceride lipase (ATGL) gene in birds. Nie Q, et al. Mol Biol Rep, 2010 Oct. PMID 20091124
  4. Cloning of adipose triglyceride lipase complementary deoxyribonucleic acid in poultry and expression of adipose triglyceride lipase during development of adipose in chickens. Lee K, et al. Poult Sci, 2009 Mar. PMID 19211534
  5. The patatin-like lipase family in Gallus gallus. Saarela J, et al. BMC Genomics, 2008 Jun 12. PMID 18549477, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association analyses showed that c.950+24C>A, c.950+45C>G, c.950+73G>A, c.950+83C>T and c.950+128delA of chicken ATGL gene (cATGL) were all significantly or highly significantly with cingulated fat width.
    Title: Identification and characterization of adipose triglyceride lipase (ATGL) gene in birds.
  2. The genetic effects of ATGL gene SNPs on chicken growth and fat traits.
    Title: Associations of ATGL gene polymorphisms with chicken growth and fat traits.
  3. The effect of food deprivation and refeeding on the expression of ATGL in adipose tissue and liver of broiler chickens is reported.
    Title: Regulation of adipose triglyceride lipase by fasting and refeeding in avian species.
  4. Results describe the cloning, sequencing, and mRNA real-time analyses of the chicken adipose triglyceride lipase gene.
    Title: cDNA cloning, characterization, and variation analysis of chicken adipose triglyceride lipase (ATGL) gene.
  5. This study showed that expression of the chicken adipose triglyceride lipase (ATGL) is adipose specific and regulated developmentally, suggesting that a possible modulation of ATGL expression would regulate fat deposition in avian species.
    Title: Cloning of adipose triglyceride lipase complementary deoxyribonucleic acid in poultry and expression of adipose triglyceride lipase during development of adipose in chickens.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
patatin-like phospholipase domain-containing protein 2
Names
PNPLA2/ATGL
adipose triglyceride lipase
NP_001106762.2
XP_015142105.3
XP_046774849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113291.2 → NP_001106762.2  patatin-like phospholipase domain-containing protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000214
    UniProtKB/TrEMBL
    A0A1D6UPP6, B3TZB4, B5AIG4, F1N831
    Related
    ENSGALP00010039742.1, ENSGALT00010065280.1
    Conserved Domains (1) summary
    cd07220
    Location:4 → 252
    Pat_PNPLA2; Patatin-like phospholipase domain containing protein 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15350110..15376279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015286619.4 → XP_015142105.3  patatin-like phospholipase domain-containing protein 2 isoform X1

    Related
    ENSGALP00010039741.1, ENSGALT00010065279.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15320307..15346486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046918893.1 → XP_046774849.1  patatin-like phospholipase domain-containing protein 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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